Although artificial micromotors have undergone tremendous progress in recent years, their fabrication normally requires complex steps or expensive equipment. In this paper, we report a facile one-step method based on an emulsion solvent evaporation process to fabricate multifunctional micromotors. By simultaneously incorporating various components into an oil-in-water droplet, upon emulsificati...

Uniform-sized biodegradable PLA/PLGA microcapsules loading recombinant human insulin (rhI) were successfully prepared by combining a Shirasu Porous Glass (SPG) membrane emulsification technique and a double emulsion-evaporation method. An aqueous phase containing rhI was used as the inner water phase (w1), and PLA/PLGA and Arlacel 83 were dissolved in a mixture solvent of dichloromethane (DCM) ...

The cause of initial burst release of hydrophilic macromolecular drugs from biodegradable polymeric microspheres was identified. Poly(D,L-lactic-co-glycolic acid) microspheres encapsulating fluorescein isothiocyanate (FITC)-labled dextran was prepared by a double emulsion solvent evaporation method. The extent of initial burst release was examined by varying the formulation process conditions s...

This study develops a new solvent-compatible microfluidic chip based on phenol formaldehyde resin (PFR). In addition to its solvent-resistant characteristics, this microfluidic platform also features easy fabrication, organization, decomposition for cleaning, and reusability compared with conventional chips. Both solvent-dependent (e.g., polycaprolactone) and nonsolvent-dependent (e.g., chitosa...

The present study involves preparation and evaluation of gastric-mucoadhesive microparticles with Metformin Hydrochloride as model drug for prolongation of gastric residence time. The microparticles were prepared by the emulsification solvent evaporation technique using polymers of Carbomer 934p (CP) and Ethylcellulose (EC). The microparticles were prepared by emulsion solvent evaporation metho...

The aim of the present work was to formulate and evaluate betahistine-loaded chitosan microspheres intended for nasal delivery with focus on their mucoadhesive properties. Betahistine-loaded chitosan microspheres were obtained via W/O emulsion solvent evaporation technique and were characterized for particle size, surphace morfology and entrapment efficiency. FTIR spectroscopy was carried out t...

The success in the preparation of Eudragit RS100 microspheres in 0.IN HCI solution using gelatin as antiaggregating agent, encouraged the selection of an acidic drug to be encapsulated using a solvent evaporation technique [1]. Ibuprofen is a non-steroidal, anti-inflammatory, analgesic and antipyretic drug approved for use as adjunct therapy in the treatment of rheumatoid and osteoarthritis [2]...

objective(s): the purpose of this study was preparation and evaluation of plga nanospheres containing the influenza virus and different adjuvants, quillaja saponin (qs) and cpg-odn.   materials and methods: nanospheres were prepared using the double emulsion-solvent evaporation method. the morphological and physicochemical properties were studied by scanning electron microscopy (sem), determina...

Natural plant extracts have been shown as effective and attractive dental biomaterials with promising properties for restorative/reparative procedures. These bioactive extracts, however, may lose their stability when exposed to air, moisture, or light, if not well-protected. Here, we present a novel technique for sequestering bioactive extracts within polymer microcapsules for long-term stabili...