Objective: In this study, it was aimed to prepare Vancomycin loaded poly(lactic acid-co-glycolic acid) (PLGA) nanoparticles that can be used parenterally in enterococcal infections. Material and Method: the different concentrations of PLGA were nanoparticles. Emulsification-solvent evaporation method preparation particles. Particle size distribution, zeta potential, encapsulation efficiency yie...

Perfluorocarbon (PFC) double emulsions loaded with a water-soluble, therapeutic agent can be triggered by ultrasound in a process known as acoustic droplet vaporization. Elucidating the stability and biodistribution of these sonosensitive vehicles and encapsulated agents is critical in developing targeted drug delivery strategies using ultrasound. [(18) F]fluorodeoxyglucose (FDG) was encapsulat...

thymol, an important and advantageous component of many essential oils, has been applied as an antimicrobial agent in animals. to increase the duration of action of this compound in ruminants, it was decided here to prepare a controlled release carrier for thymol. hydroxy propyl methyl cellulose (hpmc) and ethyl cellulose (ec) were used as the matrix polymer here. mixtures of thymol with eight ...

This research describes the role of starch nanoparticles in stabilizing surfactant-free emulsion, namely Pickering emulsion. However, concentration and NaOH during preparation as a emulsifier have not been studied. Thus, this study aimed to obtain proper concentrations when preparing breadfruit-based emulsifiers for varied (1, 3,or 5 (%(w/v)) (0.1875 0.375 M) form dispersion. Starch were acquir...

Purpose: Ofloxacin is a fluoroquinolone with broad-spectrum antibacterial action, used in treatment of systemic and local infections. Ofloxacin is BCS class II drug having low solubility, high permeability with short half-life. The present work was aimed to design, develop and optimize gellified emulsion of Ofloxacin to provide site targeted drug delivery. Transdermal drug delivery will enhance...

Objective(s) Theophylline, a xanthenes derivative, is still widely used as an effective bronchodilator in the management of asthmatic patients. It is used both as a prophylactic drug and to prevent acute exacerbations of asthma. The aim of study was to formulate and evaluate effect of the microencapsulation of theophylline loaded nanoparticles on the reduction of burst release. Materials and Me...

Insulin-loaded PEG2-PLA40 and PEG5-PLA20 microspheres containing 5% bovine insulin were manufactured using single emulsion and w/o/w multiple emulsion-solvent evaporation techniques. Microspheres were characterized for their insulin encapsulation efficiency and release characteristics in phosphate-buffered saline (PBS) at pH 7.4 and 37 ÂC. Moreover, the stability of the peptide during 18 days o...