Background: The overexpression of interferon (IFN)c or interleukin (IL)-13 in the adult murine lung induces the development of changes that mirror human lung emphysema. Methods: IL-13 and IFNc expression was determined in lung samples from five groups of patients: severe emphysema without a1-antitrypsin deficiency (SE+, n = 10); severe emphysema with a1-antitrypsin deficiency (SE2, n = 5); mild...

A personalized approach to the treatment of a polygenic disease, such as pulmonary emphysema, provides unique opportunities for selection effective in each clinical case. Progress understanding molecular mechanisms behind emphysema allows take new look at classification, causes phenotype variability, prognosis and preventive measures before manifestation. The aim this review was bring together ...

The intraoperative development of tissue-space emphysema in a child undergoing restorative treatment under general anesthesia is presented. Emphysema development seems to be concomitant with the use of compressed air around patent root canals, complicated by tissue destruction due to movement of canal irrigants/medicaments into the periapical tissues and by secondary infection. Several recommen...

BACKGROUND The diagnostic criteria of asthma-COPD overlap syndrome (ACOS) are controversial. Emphysema is characteristic of COPD and usually does not exist in typical asthma patients. Emphysema in patients with asthma suggests the coexistence of COPD. Quantitative computed tomography (CT) allows repeated evaluation of emphysema noninvasively. We investigated the value of quantitative CT measure...

A novel approach of size-based emphysema clustering has been developed, and the size variation and collapse of holes in emphysema clusters are evaluated at inspiratory and expiratory computed tomography (CT). Thirty patients were visually evaluated for the size-based emphysema clustering technique and a total of 72 patients were evaluated for analyzing collapse of the emphysema hole in this stu...

We used a CT program "density mask" outlining areas with attenuation values less than -910 HU, to indicate areas of emphysema on a chest CT and to provide an overall percentage of lung involvement by emphysema. The "density mask" quantitation of emphysema was previously shown to correlate well with the pathologic assessment of emphysema in patients undergoing lung resection. We compared the CT ...

Over the past four years (1360-1364) we have surgically treated seven infants for lobar emphysema. The pathologic lesion in all patients was in upper lobe of the left lung. Respiratory distress and pneumonia are the cardinal symptoms of patients with this abnormality. Diagnosis is confirmed by chest x-ray. The treatment of choice is lobectomy of affected lobe. 

BACKGROUND Combined idiopathic pulmonary fibrosis (IPF) and emphysema (CPFE) has been reported to be more common in male smokers. A number of studies comparing CPFE patients with fibrosis-only patients have reported a similar prognosis while others have reported a significantly shorter survival. OBJECTIVES In present study, we aimed to compare baseline characteristics of patients with IPF acc...

UNLABELLED INTRODUCTION Pulmonary interstitial emphysema is a serious complication of mechanical ventilation and can become life-threatening if progression occurs. Therapeutic lung puncture is a treatment option for severe pulmonary interstitial emphysema but has a limited use in babies with extremely low birth weight. We present a case of pulmonary interstitial emphysema in a Japanese baby ...

BACKGROUND In an earlier study of gold miners men with silicosis were found to have abnormal lung function, including airflow obstruction and reduced diffusing capacity. In a follow up study a sample of these men was examined by computed tomography to determine whether emphysema accounted for these abnormalities, which are associated with silicosis in this working population. METHODS A sample...