نتایج جستجو برای: ellman assay
تعداد نتایج: 221895 فیلتر نتایج به سال:
BACKGROUND Human butyrylcholinesterase (huBChE) has been shown to be an effective antidote against multiple LD50 of organophosphorus compounds. A prerequisite for such use of huBChE is a prolonged circulatory half-life. This study was undertaken to produce recombinant huBChE fused to human serum albumin (hSA) and characterize the fusion protein. RESULTS Secretion level of the fusion protein p...
BACKGROUND β-amyloid is regarded as a significant factor in Alzheimer's disease: but inefficient therapies based on this rationale suggests that additional signalling molecules or intermediary mechanisms must be involved in the actual initiation of the characteristic degeneration of neurons. One clue could be that acetylcholinesterase, also present in amyloid plaques, is aberrant in peripheral ...
Abstract This an apologia to Williams, P. F. (2022). The decline of substance over form in accounting: A problematic dichotomy. Accounting, Economics, and Law: Convivium critique Fischer, D., Ellman, O., & Schochet, S. (2021). accounting. , 20190052 article about the concept “substance form” has traditionally been a guiding principle for practicing accountants. In recent years, FASB taken a...
This paper presents a protocol for routine assays of human blood cholinesterase activities which separates erythrocytes from plasma by centrifugation and measures acetylcholinesterase activity in unwashed erythrocytes and butyrylcholinesterase activity in the plasma. The recommended substrate for both enzymes is 1.0 mM acetylthiocholine. The protocol is compared with other two recommended proto...
Four new mexicanolide-type limonoids 1-4, along with two known limonoids 5-6, were isolated from the ethanolic extracts of roots of the Traditional Chinese Medicine Trichilia sinensis. Their structures were unambiguously determined by analysis of spectroscopic data, including 1D and 2D NMR as well as MS, and by comparison with literature data. In addition, the acetylcholinesterase (AChE) inhibi...
It is well known that lung affections may be accompanied by so-called hypertrophic pulmonary osteo-arthropathy, which seems to be almost regularly associated with mild joint symptoms. Bamberger (1889) and Marie (1890) first studied this syndrome, but little attention has been paid to the misleading resemblance of these joint symptoms to those seen in the early stages of rheumatoid arthritis, th...
Platelet-derived growth factor (PDGF)-C is a novel member of the PDGF family that binds to PDGF alphaalpha and alphabeta receptors. The growth factor domain of PDGF-C (GFD-PDGF-C) was expressed in high yields in Escherichia coli and was purified and refolded from inclusion bodies obtaining a biologically active growth factor with dimeric structure. The GFD-PDGF-C contains 12 cysteine residues, ...
Alzheimer's disease (AD), the most common form of dementia, is a neurodegenerative disease characterized by progressive cognitive deterioration together with declining activities of daily living and neuropsychiatric symptoms or behavioural changes. The oldest, on which most currently available drug therapies are based, is known as the "cholinergic hypothesis" and suggests that AD begins as a de...
Pulmonary involvement with Hodgkin's disease has been estimated to occur in 40% of most large series (Ellman and Bowdler, 1960; Sternberg, Sidransky and Ochsner, 1959). Primary pulmonary Hodgkin's disease is most uncommon, and in Kern's review of the literature only 18 cases were noted to fulfill the criteria that were established by the authors (Kern, Crepeau and Jones, 1961). Since that time ...
We present a case of a 45-year-old patient who reported bleeding hemorrhoids. He had grade II hemorrhoids and was found to have a circumferential leukoplakic lesion at the anal verge. The patient had no symptoms of leukoplakia. The hemorrhoids were ablated with an Ellman radiowave device. Histological findings of the incised lesion from the verge showed hyperkeratosis and acanthosis extending c...
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