This study reports on the potential of using ion-exchange suppressor technology in liquid chromatography—electrospray ionization mass spectrometry workflows. The aim was to use high salt concentrations improve separation performance, while overcoming resulting significant ion suppression during electrospray ionization. As a case study, we apply hydrophilic interaction chromatography and detecti...

A new method of desorption ionization is described and applied to the ionization of various compounds, including peptides and proteins present on metal, polymer, and mineral surfaces. Desorption electrospray ionization (DESI) is carried out by directing electrosprayed charged droplets and ions of solvent onto the surface to be analyzed. The resulting mass spectra are similar to normal ESI mass ...

The ionic liquid [Bmim][DCA] is a propellant candidate in a standalone electrospray thruster or in a dual-mode propulsion system consisting of a chemical system and an electrospray system. Since limited published data exists for [Bmim][DCA], the electrospray characteristics are relatively unknown. Emission testing of the ionic liquid has been conducted to characterize the [Bmim][DCA] electrospr...

The lack of authentic standards has limited the quantitative analysis of herbal drugs in biological samples. The present work demonstrated a practicable strategy for the assay of herbs and their metabolites independent of authentic standards. A liquid chromatography–electrospray ionization–mass spectrometry (LC–ESI–MS) method for the qualitative and quantitative determination of the metabolites...

The lack of authentic standards has limited the quantitative analysis of herbal drugs in biological samples. The present work demonstrated a practicable strategy for the assay of herbs and their metabolites independent of authentic standards. A liquid chromatography–electrospray ionization–mass spectrometry (LC–ESI–MS) method for the qualitative and quantitative determination of the metabolites...

Mass Spectrometry The ionization of N-protonated Verapamil by electrospray (ESI) is investigated in the Communication (e202116794) W. Scott Hopkins et al. using differential mobility spectrometry (DMS). spectral behaviour caused protonation-induced chirality.

Hydrogen-exchange electrospray-ionization mass spectrometry is demonstrated to be an effective new method for probing conformational changes of proteins in solutions. The method is based on the mass spectrometric measurement of the extent of hydrogen/deuterium exchange that occurs in different protein conformers over defined periods of time. Results are presented in which hydrogen-exchange elec...

Citation: Nixon RL and Ross ARS (2016) Evaluation of Immobilized Metal-Ion Affinity Chromatography and Electrospray Ionization Tandem Mass Spectrometry for Recovery and Identification of Copper(II)-Binding Ligands in Seawater Using the Model Ligand 8-Hydroxyquinoline. Front. Mar. Sci. 3:246. doi: 10.3389/fmars.2016.00246 Evaluation of Immobilized Metal-Ion Affinity Chromatography and Electrospr...

A specialized isotope mass spectrometer for determining the isotopic ratio of lithium by ERIAD (electrospray with atomization in an ion source) is described. The device uses a Mattuha-Herzog-type analyzer double focusing to use beams large spread energy and simultaneous registration signals both isotopes ( 6 Li 7 Li), two-channel receiver based on doublet microchannel plates. gas-dynamic interf...