In this review, we provide an overview of the strategies developed by caliciviruses to subvert or regulate the host protein synthesis machinery to their advantage. As intracellular obligate parasites, viruses strictly depend on the host cell resources to produce viral proteins. Thus, many viruses have developed strategies that regulate the function of the host protein synthesis machinery, often...

Eukaryotic translation initiation factors are the principal molecular effectors regulating the process converting nucleic acid to functional protein. Commonly referred to as eIFs (eukaryotic initiation factors), this suite of proteins is comprised of at least 25 individual subunits that function in a coordinated, regulated, manner during mRNA translation. Multiple facets of eIF regulation have ...

The popularity of wireless communication has increased substantially over the last decade, due to mobility support, flexibility and ease of deployment. Among next generation of mobile communication technologies, Ad Hoc networking plays an important role, since it can stand alone as private network, become a part of public network, either for general use or as part of disaster management scenari...

Translation initiation in eukaryotes is mediated by a large group of eukaryotic translation initiation factors (eIFs) that coordinate the recruitment of 50-capped mRNAs and ribosomal subunits. Human eIF4GI is a scaffold protein which interacts with other eIFs in various ways: in a large complex, elF4F, with eIF4A and eIF4E; the interaction between eIF3 and eIF4GI places the 40S ribosome next to...

Additive manufacturing of metallic parts via laser powder bed fusion has is attractive for applications such as aerospace engineering due to the high weight-saving potential, which based on ability process produce complex designs. The aluminum alloy Scalmalloy® can increase this potential lightweight design further with its strength and ductility. These advantages already led a variety use case...

Abstract Background Hepatocellular carcinoma (HCC) is one of the most common cancers with high incidence and mortality. However, underlying mechanisms HCC still remain unclear. Eukaryotic translation initiation factors (eIFs) have a substantial effect on tumor development. In this study, we were aimed to investigate role eukaryotic factor 4 gamma 2 (EIF4G2) in HCC. Methods Western blot (WB) 30 ...

The eukaryotic initiation factor 3 (eIF3) plays an important role in translation initiation, acting as a docking site for several eIFs that assemble on the 40S ribosomal subunit. Here, we use mass spectrometry to probe the subunit interactions within the human eIF3 complex. Our results show that the 13-subunit complex can be maintained intact in the gas phase, enabling us to establish unambiguo...