Endogenous small interfering RNAs (endo-siRNAs) have been discovered in many organisms, including mammals. In C. elegans, depletion of germline-enriched endo-siRNAs found in complex with the CSR-1 Argonaute protein causes sterility and defects in chromosome segregation in early embryos. We discovered that knockdown of either csr-1, the RNA-dependent RNA polymerase (RdRP) ego-1, or the dicer-rel...

The ego-depletion effect refers to a temporary failure of self-control exertion after first performing an effortful task. This phenomenon has experienced replication crisis in the past few years. In present series experiments, we tried replicate using 30-min modified Stroop task tapping two executive functions (inhibitory control and cognitive flexibility) as depleting study, compared performan...

Ego depletion refers to decrements in self-control performance resulting from prior use of self-control. The ego effect has received much research attention, but the more recent literature reports small or null effects. This registered report examined moderating task similarity on effect. We predicted a crossover interaction between type primary and secondary such that engaging demanding should...

OBJECTIVE The difficulty for chronic dieters (i.e. restrained eaters) in regulating their food intake is a conflict between two apparently incompatible goals: eating enjoyment and weight control. The latter goal consistently relies on the deployment of cognitive resources, and very often on a significant amount of self-control. This study investigated whether self-affirmation might counteract t...