Modification of bovine adrenodoxin with 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) dramatically inhibited the reaction with adrenodoxin reductase (EC 1.18.1.2). The modification did not cause any change in the visible spectrum of adrenodoxin, indicating that the iron-sulfur center was not perturbed. Furthermore, the anomalous fluorescence of Tyr 82 was not changed in either intensity o...

Engineering Design Communication (EDC) is fundamental to almost all Engineering Design activities as it provides the ability for knowledge and information to be shared between engineers. It is part of ‘what we do’. This communication contains a great deal of rationale relating to the evolution of Product Development and is essential for understanding ‘why the product is the way it is’. The need...

The evolution of amniotes has involved major molecular innovations in the epidermis. In particular, distinct structural proteins that undergo covalent cross-linking during cornification of keratinocytes facilitate the formation of mechanically resilient superficial cell layers and help to limit water loss to the environment. Special modes of cornification generate amniote-specific skin appendag...

The epidermal differentiation complex (EDC) is the most rapidly evolving locus in the human genome compared to that of the chimpanzee. Yet the EDC genes that are undergoing positive selection across mammals and in humans are not known. We sought to identify the positively selected genetic variants and determine the evolutionary events of the EDC using mammalian-wide and clade-specific branch- a...

The epidermal differentiation complex (EDC), located on chromosomal band 1q21, consists of at least 43 genes that are expressed during keratinocyte differentiation. Indicative of a role for chromatin structure in tissue specificity of EDC gene expression, we identified an inverse correlation between expression and DNA methylation for two EDC genes (S100A2 and S00A6) in human keratinocytes and f...

Acknowledgments. The Envisionment and Discovery Collaboratory (EDC) is a long-term research effort with the contributions of many researchers in L3D. Special thanks go to:  Ernesto Arias, whose work and ideas inspired the whole effort and who envisioned and initiated numerous major developments; and  Eric Scharff , who in the context of his PhD research, developed essential parts of the first...

Gas is trapped in polar ice sheets at ∼50–120m below the surface and is therefore younger than the surrounding ice. Firn densification models are used to evaluate this ice age-gas age difference (∆age) in the past. However, such models are not well tested on low accumulation and cold sites of the East Antarctic plateau, especially for 5 periods with different climatic conditions. Here we bring ...

OBJECTIVE Endocrine-disrupting chemicals (EDCs) adversely affect human health. Our objective was to determine the association of EDC exposure with earlier age of menopause. METHODS Cross-sectional survey using National Health and Nutrition Examination Survey (NHANES) data from 1999 to 2008 (n = 31,575 females). Eligible participants included: menopausal women >30 years of age; not currently p...

Philip Jacob, is Program Development Coordinator, Segal Design Institute, Northwestern University, Evanston,, Illinois. The Segal Design Institute in the McCormick School of Engineering at Northwestern University offers an innovative design course called Engineering Design and Communication (EDC). EDC is a required program for all engineering undergraduates and is generally taken in their fresh...