BACKGROUND AND PURPOSE Radiostereometric analysis (RSA) is a highly accurate tool for assessment of polyethylene (PE) wear in total hip arthroplasty (THA); however, PE wear measurements in clinical studies are often limited to plain radiographs. We evaluated the agreement between PE wear measured with PolyWare software, which uses plain radiographs, and by model-based RSA, which uses stereo rad...

Monte Carlo Event Generators (EGs) have developed into essential tools in High Energy Physics. Without them it is questionable if it at all would be possible to embark on large scale experiments such as the LHC. Although the current EGs work satisfactorily, the next generation of experiments will substantially increase the demands both on the physics models implemented in the EGs and on the und...

A nalysing, in 1997, the likely impact of electronic commerce is about as easy as estimating the impact of the automobile a hundred years ago. Intuitively you know that the impact will be large, but as yet few people know how to drive, roads are of varying quality and garages and mechanics are nearly non-existent. With some confidence you can say that there will be a beneficial effect on supply...

Accurate and efficient detection of sleep spindles is a methodological challenge. The present study describes a method of using non-experts for manual detection of sleep spindles. We recruited five experts and 168 non-experts to manually identify spindles in stage N2 and stage N3 sleep data using a MATLAB interface. Scorers classified each spindle into definite and indefinite spindle (with weig...

Based on a review of the Enhanced Geothermal Systems (EGS) developed to date, numerical simulation of idealized EGS reservoirs, economic sensitivity analysis, and practical considerations of certain site characteristics, this paper shows that certain steps can be taken towards optimizing the economics of an EGS project: These steps, in decreasing order of their importance, are as follows: (a) r...

This paper describes a constraint transformation approach to automatic example generation and its implementation. In this approach examples are generated as the result of successive transformations of the constraint formulas. Such transformations are carried out based on various forms of knowledge. Systematic global simplification, largely based on declarative knowledge, mitigates the impact of...

External guide sequences (EGSs) are small RNA molecules which consist of a sequence complementary to a target mRNA and render the target RNA susceptible to degradation by ribonuclease P (RNase P). EGSs were designed to target the mRNA encoding thymidine kinase (TK) of herpes simplex virus 1 for degradation. These EGSs were shown to be able to direct human RNase P to cleave the TK mRNA sequence ...

In a model selection procedure where many models are to be compared, computational efficiency is critical. For acyclic digraph (ADG) Markov models (aka DAG models or Bayesian networks), each ADG Markov equivalence class can be represented by a unique chain graph, called an essential graph (EG). This parsimonious representation might be used to facilitate selection among ADG models. Because EGs ...

The deliberate inhibition of expression of one of the protein subunits (Rpp38) of human nuclear RNase P is achievable by using external guide sequence (EGS) technology. Both the protein product and the mRNA are greatly reduced 24 h after transient transfection with a gene coding for an appropriate EGS. Control experiments indicated that four other protein subunits of RNase P and their RNAs are ...

Gamification is the concept of applying game elements in non-game context platforms to motivate people to participate in planned activities to achieve goals. Gamification has been applied to academic fields including software engineering (SE) in recent years. Many gamification implementations in SE have been ad hoc and lacked standardized guidelines. This paper introduces a new concept of build...