Breast cancer is one of the most common and lethal cancers in women. As a hub gene involved in a diversity of tumors, the ubiquitin-conjugating enzyme H10 (UbcH10), may also play some roles in the genesis and development of breast cancer. In the current study, we found that the expression of UbcH10 was up-regulated in some breast cancer tissues and five cell lines. We established a dual drug re...

An effective polarizable bond (EPB) model has been developed for computer simulation of proteins. In this partial polarizable approach, all polar groups of amino acids are treated as polarizable, and the relevant polarizable parameters were determined by fitting to quantum calculated electrostatic properties of these polar groups. Extensive numerical tests on a diverse set of proteins (includin...

BACKGROUND Development of the epidermal permeability barrier (EPB) is essential for neonatal life. Defects in this barrier are found in many skin diseases such as atopic dermatitis. OBJECTIVE We investigated the effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the development and function of the EPB. METHODS Timed-pregnant C57BL/6J mice were gavaged with corn oil or TCDD (10 μg/kg b...

The `Eastern Paci¢c Barrier' (EPB), 5400 km of uninterrupted deep water between the central and eastern Paci¢c, constitutes the greatest marine obstacle to the dispersal of shallow-water organisms. However, some species are found on both sides of the EPB.These `transpaci¢c' species are considered by `dispersal' biogeographers as evidence of invasions through the barrier. `Vicariance' biogeograp...

To develop new photoinduced electron-transfer (PET) reagents, we established a method for predicting the fluorescence quantum yields (phi) of the benzofurazan compounds bearing an aliphatic substituent group having an n-electron. The PET process occurred sufficiently to reduce the phi values in the benzofurazan compounds bearing an aliphatic moiety, which had a high quenching ability. The quenc...

−This paper describes a parallel model-based fault detection algorithm for an electronic parking brake (EPB) system, which consists of an electronic control unit with built-in current sensor and braking force sensor. For the EPB system to supply sufficient parking force to a vehicle, the parking force sensor is of utmost importance. If a fault occurs in this sensor, sufficient parking force may...

CONTEXT The yield of in-hospital stool cultures performed more than 72 hours after admission is low, and a commonly used policy dictates that laboratories reject these cultures to save costs. However, enteropathogenic bacteria other than Clostridium difficile (EPB) may cause nosocomial illness that would be missed by use of such a "3-day rule." OBJECTIVE To develop guidelines for hospital use...