abstract objective: to assess the incidence of thrombocytopenia and changes in various platelet parameters, in culture positive neonatal sepsis. methods: this was prospective study conducted over a period of one year from december 2009 to november 2010 in neonatal intensive care unit of dduh hospital, a tertiary care hospital in delhi, north india. all babies who were admitted during this perio...

The role of receptor phosphorylation on the redistribution of β-adrenergic receptors (β-ARs) in rat hearts during different phases of sepsis was investigated. Sepsis was induced by cecal ligation and puncture (CLP). Changes in the distribution of β-ARs in the sarcolemmal and light vesicle fractions were studied using (-)-[4,6-propyl-3H]dihydroalprenolol ([3H]DHA). Phosphorylation of β-ARs was s...

Sepsis is an inflammatory response triggered by infection, with risk of in-hospital mortality fueled by disease progression. Early recognition and intervention by multidisciplinary sepsis programs may reverse the inflammatory response among at-risk patient populations, potentially improving outcomes. This retrospective study of a sepsis program enabled by a 2-stage sepsis Clinical Decision Supp...

background: symmetrical peripheral gangrene is usually associated with underlying medical problems and it is seldom seen in pregnancy. sepsis though common in a setting of delivery by unskilled midwife is rarely accompanied by symmetrical gangrene. case presentation: we report a case of symmetrical peripheral gangrene which occurred in the winter, triggered possibly by sepsis and a single dose ...

SEPSIS is a complex clinical syndrome involving both infection and a deleterious host immune response. Actue Kidney Injury (AKI) is a frequent and serious complication of sepsis in Intensive Care Unitpatient (ICU). Despite recent impressive advances in the pathophysiology, diagnostic procedures, and appropriate therapeutic interventions in sepsis, sepsis-induced AKI fails to reduce the overwhel...

BACKGROUND Infants born to mothers who are colonized with group B streptococcus (GBS) but received <4 hours of intrapartum antibiotic prophylaxis (IAP) are at-risk for presenting later with sepsis. We assessed if <4 hours of maternal IAP for GBS are associated with an increased incidence of clinical neonatal sepsis. MATERIALS AND METHODS A retrospective cohort study of women-infant dyads unde...

Neonatal sepsis is a life-threatening disease. Early diagnosis essential, but no single marker of infection has been identified. Sepsis activates coagulation cascade with simultaneous production the D-dimers due to lysis fibrin. D-dimer test reflects activation system.