نتایج جستجو برای: e7

تعداد نتایج: 3670  

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1998
S Song G A Gulliver P F Lambert

E6 and E7 oncoproteins from high risk human papillomaviruses (HPVs) transform cells in tissue culture and induce tumors in vivo. Both E6, which inhibits p53 functions, and E7, which inhibits pRb, can also abrogate growth arrest induced by DNA-damaging agents in cultured cells. In this study, we have used transgenic mice that express HPV-16 E6 or E7 in the epidermis to determine how these two pr...

Journal: :The Journal of biological chemistry 2000
J S Park S Boyer K Mitchell D Gilfor M Birrer G Darlington W El Deiry G L Firestone K Munger V Band P B Fisher P Dent

The impact of human papilloma virus (HPV16) E7 proteins and retinoblastoma (RB) antisense oligonucleotides upon mitogen-activated protein kinase (MAPK)-mediated inhibition of DNA synthesis via p21(Cip-1/WAF1/MDA6) (p21) was determined in primary hepatocytes. Prolonged activation of the MAPK pathway in p21(+/+) or p21(-/-) hepatocytes caused a large decrease and increase, respectively, in DNA sy...

2013
Wen-Fang Cheng Ming-Cheng Chang Wei-Zen Sun Yu-Wei Jen Chao-Wei Liao Yun-Yuan Chen Chi-An Chen

INTRODUCTION Human papillomavirus (HPV) has been consistently implicated in causing several kinds of malignancies, and two HPV oncogenes, E6 and E7, represent two potential target antigens for cancer vaccines. We developed two fusion protein vaccines, PE(ΔIII)/E6 and PE(ΔIII)/E7 by targeting these two tumor antigens to test whether a combination of two fusion proteins can generate more potent a...

Journal: :Gynecologic oncology 2007
Chia-Yen Huang Chi-An Chen Chien-Nan Lee Ming-Cheng Chang Yi-Ning Su Yi-Chun Lin Chang-Yao Hsieh Wen-Fang Cheng

OBJECTIVE Vaccination based on tumor antigen is an attractive strategy for cancer prevention and therapy. Cervical cancer is highly associated with human papillomavirus, especially type 16. We developed DNA vaccines encoding heat shock protein 60 (HSP60) linked to HPV16 E6 or E7 to test if HSP60 chimeric DNA vaccines may generate strong E6 and/or E7-specific immune response and anti-tumor effec...

Journal: :The Journal of biological chemistry 2007
Grant A Darnell Wayne A Schroder Toni M Antalis Eleanore Lambley Lee Major Joy Gardner Geoff Birrell Angel Cid-Arregui Andreas Suhrbier

Cervical cancers transformed by high risk human papilloma virus (HPV) express the E7 oncoprotein, which accelerates the degradation of the retinoblastoma protein (Rb). Here we show that the E7-mediated degradation of Rb requires the calcium-activated cysteine protease, calpain. E7 bound and activated mu-calpain and promoted cleavage at Rb(810), with mutation of this residue preventing E7-mediat...

Journal: :The Journal of general virology 1997
A C Phillips K H Vousden

The E7 protein encoded by human papillomavirus type 16 shows transforming and immortalizing activities which are mediated, in part, through the interaction of the viral oncoprotein with the pRB protein family. This interaction is not solely responsible for E7 function, however, and other properties of E7, such as the interaction with basal transcription factors such as TBP, are likely to be of ...

Journal: :Journal of immunology 2001
W F Cheng C F Hung C Y Chai K F Hsu L He C M Rice M Ling T C Wu

Recently, self-replicating RNA vaccines (RNA replicons) have emerged as an effective strategy for nucleic acid vaccine development. Unlike naked DNA vaccines, RNA replicons eventually cause lysis of transfected cells and therefore do not raise the concern of integration into the host genome. We evaluated the effect of linking human papillomavirus type 16 E7 as a model Ag to Mycobacterium tuberc...

E7

Journal: :Arthropod Management Tests 2012

Journal: :Journal of virology 2006
Kwang-Jin Oh Anna Kalinina No-Hee Park Srilata Bagchi

Infections with high-risk human papillomaviruses (HPVs) are linked to more than 95% of cervical cancers. HPVs replicate exclusively in differentiated cells and the function of the HPV E7 oncoprotein is essential for viral replication. In this study, we investigated the mechanism that regulates E7 expression in differentiated cells. The level of E7 protein was strongly induced in HPV-containing ...

ابراهیم زاده, میرسعید, باغبان رحیمی, ساناز, سلیمان جاهی, حوریه, علیزاده, لیلا, قائمی, امیر, محبی, علیرضا,

Background & Objective: Human papillomavirus (HPV) oncoproteins, including E6 and E7 are constitutively expressed in cervical cancer cells. These proteins are ideal targets to be used for developing therapeutic vaccines against existing HPV-associated carcinomas. The aim of this study was to measure the proliferation response rate of splenic lymphocytes derived from E7-HPV16 encoding plasmid in...

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