نتایج جستجو برای: e6 papilloma virus
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purpose: to explore any association between human papilloma virus (hpv) infection and ocular surface squamous neoplasia. methods: forty pathological specimens including 20 cases of conjunctival intra-epithelial neoplasia grade i (cin i) and 20 cases of cin iii and invasive squamous cell carcinoma (scc) together with 20 pterygium samples (controls) were analyzed by polymerase chain reaction (pcr...
Human papilloma virus inoculation: why only girls? L.Z.G. Touyz bds msc(dent) mdent(perio and Oral med) REFERENCES 1. Teenagers with grown-up diseases [editorial]. Lancet 2008; 371:960. 2. Donovan B. Sexually transmissible infections other than hiv. Human papillomavirus (hpv)–related oropharyngeal nonkeratinizing squamous cell carcinoma: characterization of a distinct phenotype. Human papilloma...
introduction: the human papilloma virus (hpv) can play a role in the development of head and neck squamous cell carcinoma (scc). our aim was to assess the prevalence of hpv dna in scc of the larynx. the impact of hpv infection on patient survival was also evaluated. materials and methods: this case-control study was performed in 44 patients with scc of the larynx (case group), while the contro...
BACKGROUND/AIM The present study aimed to investigate whether the down-regulation of human telomerase reverse transcriptase (hTERT) may induce an anti-invasive effect in oral squamous cell cancer cell lines. MATERIALS AND METHODS A genetically-engineered squamous carcinoma cell line overexpressing hTERT in immortalized oral keratinocytes transfected by human papilloma virus (HPV)-16 E6/E7 (IH...
BACKGROUND Head and neck squamous cell carcinoma (HNSCC) is the sixth most common malignancy worldwide with a poor prognosis. Human papilloma virus (HPV) infection is associated with 20% HNSCC, and 50% of oropharyngeal carcinoma. HPV16 type is detected in 90% of all HPV+ HNSCC. Recently we suggested a fundamentally different approach to treatment of cancers of viral origin by targeting viral an...
Human Papilloma Virus (HPV) associated cervical cancer is amongst the ten most common cancers in women in the developing world. New vaccines markedly reduce the economic burden of diseases on a country's health system. Two types of HPV vaccines are available; prophylactic and therapeutic. Prophylactic vaccines target (Late protein) L1 and to a lesser extent L2, which stimulate neutralizing anti...
CD24 is overexpressed in nearly 70% human cancers, whereas TP53 is the most frequently mutated tumour-suppressor gene that functions in a context-dependent manner. Here we show that both targeted mutation and short hairpin RNA (shRNA) silencing of CD24 retard the growth, progression and metastasis of prostate cancer. CD24 competitively inhibits ARF binding to NPM, resulting in decreased ARF, in...
Cystinosis, the most frequent cause of inborn Fanconi syndrome, is characterized by the lysosomal cystine accumulation, caused by mutations in the CTNS gene. To elucidate the pathogenesis of cystinosis, we cultured proximal tubular cells from urine of cystinotic patients (n = 9) and healthy controls (n = 9), followed by immortalization with human papilloma virus (HPV E6/E7). Obtained cell lines...
Antibody modulation of T-cell coinhibitory (e.g., CTLA-4) or costimulatory (e.g., 4-1BB) receptors promotes clinical responses to a variety of cancers. Therapeutic cancer vaccination, in contrast, has produced limited clinical benefit and no curative therapies. The E6 and E7 oncoproteins of human papilloma virus (HPV) drive the majority of genital cancers, and many oropharyngeal tumors. We disc...
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