Objective. Necrotizing fasciitis (NF) is a predominantly adult disorder, with bacterial infection of the soft tissue. In children, it is relatively rare and has a fulminant course with a high mortality rate. In the neonate, most cases of NF are attributable to secondary infection of omphalitis, balanitis, mammitis, postoperative complications, and fetal monitoring. The objective of this communi...

Objective. Necrotizing fasciitis (NF) is a predominantly adult disorder, with bacterial infection of the soft tissue. In children, it is relatively rare and has a fulminant course with a high mortality rate. In the neonate, most cases of NF are attributable to secondary infection of omphalitis, balanitis, mammitis, postoperative complications, and fetal monitoring. The objective of this communi...

HomeStrokeVol. 52, No. 2Endovascular Therapy Versus Medical Treatment for Symptomatic Intracranial Artery Stenosis Free AccessReview ArticlePDF/EPUBAboutView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyRedditDiggEmail Jump toFree ArticlePDF/EPUBEndovascular Tao Wang, MD, Jichang Luo, Xue BS, Kun Yang, MS, Vi...

Background: Oxidative stress is an important inducer of cell apoptosis and plays a key role in the development of renal inflammation. The prostate apoptosis response factor-4 (Par-4) gene was originally identified in prostate cells undergoing apoptosis. Subsequently, Par-4 was found to possess potent pro-apoptotic activity in various cellular systems. However, it remains unclear whether Par-4 i...

Editor—The British cycling team won eight gold medals at the 2012 London Olympics. This success, it has been suggested, was attributable, in part, to philosophy of ‘the aggregation marginal gains’: small improvements every day, everywhere and anywhere, that have a compound effect. concept gained traction clinical anaesthesia perioperative medicine; we believe should likewise be applied sustaina...

Knowledge intensive processes are often driven and constrained by the mental models of experts acting as direct participants or managers. Descriptions of these relationships are not generally available from traditional data sources but are stored in the mental models of experts. Often the knowledge is not explicit but tacit, so it is dicult to describe, examine, and use. Consequently, improvem...

In addition to perspectives, reviews, and original research articles, CPT:PSP welcomes a special type of articles in the fields of Pharmacometrics and Systems Pharmacology: Tutorials. A CPT:PSP tutorial is intended as an “educational article providing practical tutorial on tools, methodologies, and approaches.” Tutorials aim to increase the awareness and potential of Pharmacometrics and Systems...

We compare our model of unsupervised learning of linguistic structures, ADIOS [1, 2, 3], to some recent work in computational linguistics and in grammar theory. Our approach resembles the Construction Grammar in its general philosophy (e.g., in its reliance on structural generalizations rather than on syntax projected by the lexicon, as in the current generative theories), and the Tree Adjoinin...

Substantial progress has been made in understanding the genetic basis of temperature-compensated circadian clocks. Ultradian rhythms, with a period shorter than 24 h, are at least as widespread as circadian rhythms. We have initiated genetic analysis of defecation behavior, which is controlled by an ultradian clock in Caenorhabditis elegans. The defecation motor program is activated every 45 se...

On the basis of a category system that classifies metacognitive activities, the first part of this paper shows to what extent reflection can be understood as one of several metacognitive activities. It is then demonstrated that it proved to be useful to consider different nuances of reflection. Illustrated by examples taken from math classes on grammar school level, the second part of the essay...