Endothelial adherens junctions maintain vascular integrity. Arteries and veins differ in their permeability but whether organization and strength of their adherens junctions vary has not been demonstrated in vivo. Here we report that vascular endothelial cadherin, an endothelial specific adhesion protein located at adherens junctions, is phosphorylated in Y658 and Y685 in vivo in veins but not ...

The vascular effects of antiangiogenic treatment may pose problems for evaluating brain tumor response based on contrast-enhanced magnetic resonance imaging (MRI). We used serial dynamic contrast-enhanced MRI at 12 T to assess vascular responses to antiangiogenic versus steroid therapy. Athymic rats with intracerebral U87MG human glioma (n=17) underwent susceptibility-weighted perfusion MRI wit...

To take capillary effect into account, a series of primary drainage experiments of water by a sample oil fluid have been studied. The experiments performed under different low flow rates on a horizontal glass type micromodel as a model of porous media. Based on conventional macroscopic flow equations, the relative permeabilities and capillary pressure are determined by parameter estimation tech...

This brief review assesses the role of Ca2+ signaling in lung endothelium in regulation of endothelial permeability. The disconnect between experimental and clinical outcomes to date may be due, in part, to the use of tools which yield information about aggregate permeability or Ca2+ responses in lung or in endothelial monolayers. The teaching point of this review is to "unpack the box," i.e. c...

In tissue engineering, porous biodegradable scaffolds are used as templates for regenerating required tissues. With the advances in computational tools, many modeling approaches have been considered. For example, fluid flow through porous medium can be modeled using the Brinkman equation where permeability of the porous medium has to be defined. In this review, we summarize various models recen...

BACKGROUND AND PURPOSE The pituitary gland is located outside of the blood-brain barrier. Dynamic T1 weighted contrast enhanced sequence is considered to be the gold standard to evaluate this region. However, it does not allow assessment of intrinsic permeability properties of the gland. Our aim was to demonstrate the utility of radial volumetric interpolated brain examination with the golden-a...

A geostatistically-based inverse technique, the sequential-self calibration (SSC) method, is used to update reservoir models so that they match observed pressure, water cut and time-lapse water saturation derived from 4-D seismic. Within the SSC, a steady-state genetic algorithm (GA) is applied to search the optimal master point locations, as well as the associated optimal permeability perturba...

The frequency dependences of complex initial permeability for triplecomponent composite materials based on two different types of ferrite filler (MnZn and NiZn ferrite) and a nonmagnetic polymeric matrix (PVC) were studied in the frequency range of 10 kHz–1 GHz. The frequency dispersion of permeability is discussed by means of a dynamic model based on the superposition of the two types of magne...

The dynamics of BBB permeability after AIS in humans are not well understood. In the present study we measured the evolution of BBB permeability after AIS in humans using MRI. Patients presenting to our institution with a diagnosis of AIS underwent a single dynamic contrast-enhanced MRI (DCE-MRI) sequence to measure BBB permeability during their initial workup. Forty-two patients were included ...