The hydrophobic-amphiphilic self-assembly approach has been employed to prepare molecular micro-capsules simply by cooling down an emulsion, in a hot polar solvent medium, of a melted compound having two very well-distinguished units, both with highly non-polar and hydrophobic characteristics. The resulting micro-capsules are very stable and robust both in suspension and under dry conditions. F...

Poly-(alkylcyanoacrylate) ester particles have been used for the preparation of different formulations ranging from ophthalmic delivery systems to cancer chemotherapy carriers in clinic. The aim of this study was to prepare and characterize poly-(methyl ethyl cyanoacrylate) (PMECA) particles containing 5-aminosalicylic acid (5-ASA). PMECA particles were prepared using the inverse emulsification...

BACKGROUND AND AIM Hospitalized patients requiring parenteral nutrition (PN) often need to receive intravenous (IV) medications as well. Y-site administration is occasionally necessary, but physicochemical incompatibilities can occur between the medications and PN. The aim of the present study was to assess the physical compatibility between 25 frequently coadministered IV medications and a com...

The goal of this study was to explore the effects of spray-drying on w/o/w double emulsions of methyltestosterone (MT) loaded in a stearic acid matrix. MT-loaded nanoparticles were formulated by a water-in-oil-in-water emulsion technique using 50, 75, and 100 mg of stearic acid, 2% and 3% w/v polyvinyl alcohol, 5% w/v lactose, and 0.2% w/v chitosan. The emulsions were immediately spray-dried ba...

A HeNe laser beam incident on a sample of micron-sized spheres suspended in water scatters into a random pattern of spots of varying size, shape, and intensity. The pattern results from the coherent superposition of the outgoing waves scattered from the spheres. Because the spheres are in constant Brownian motion, the pattern randomly changes in time. A photodetector is placed in the pattern an...

Two-photon microscopy is a powerful method in biomedical research that allows functional and anatomical imaging at a subcellular resolution in vivo. The technique is seriously hampered by absorption and scattering of light by blood, which prevents imaging through large vessels. Here, we demonstrate in the rat cerebral cortex that blood replacement by perfluorocarbon emulsion, a compound also us...

By scattering light from small particles, their geometrical structure and their state of motion can be measured. An experiment is described for measuring the diffusivity of small particles undergoing Brownian motion using the technique called photon correlation spectroscopy or dynamic light scattering. The necessary experimental apparatus and the related theory are discussed. Photon correlation...

Supercritical fluids extraction of emulsions (SEE) is an innovative technique used for the production of micro, nano-particles with controlled size and distribution. Supercritical carbon dioxide (SC-CO2) is used to extract selectively the organic solvents from the droplets of the emulsion, in which the biopolymer is dissolved, producing the precipitation of the polymer and the subsequent format...

A dynamic light scattering apparatus was built with a HeNe laser; the beam incident on a sample of particles(microspheres of one or multiple diameters or casein undigested and digested) suspended in water scatters into a random pattern product of the coherent superposition of the outgoing waves scattered from the spheres. Because the spheres are in constant Brownian motion, the pattern randomly...