In isolated perfused guinea pig hearts, coronary flow causes a positive inotropic effect [positive coronary flow-induced effect (+CFIE)] that could be altered by dextrans (Dx) in the coronary perfusion solution. To test this possibility, Dx of 20, 40, 70, and 500 kDa were infused and found to modulate +CFIE; however, when Dx infusion was terminated, the effect persisted, i.e., was irreversible/...

The vacuum solution ds 2 = dx 2 + x 2 dy 2 + 2 dz dt + ln x dt 2 of the Einstein gravitational field equation follows from the general ansatz ds 2 = dx 2 + g αβ (x) dx α dx β but fails to follow from it if the symmetric matrix g αβ (x) is assumed to be in diagonal form.

During development, the Notch receptor regulates many cell fate decisions by a signaling pathway that has been conserved during evolution. One positive regulator of Notch is Deltex, a cytoplasmic, zinc finger domain protein, which binds to the intracellular domain of Notch. Phenotypes resulting from mutations in deltex resemble loss-of-function Notch phenotypes and are suppressed by the mutatio...

We provide analytical functions approximating e −x 2 dx, the basis of which is the kink soliton and which are both accurate (error < 0.2%) and simple. We demonstrate our results with some applications, particularly to the generation of Gaussian random fields.

The sensitivity of three different human and murine doxonibicin (Dx)sensitive or -resistant pairs of tumor cells to recombinant interleukin 2 (rii,2)-aclivaled lymphocytes was studied. In two pairs of these sublines (LoVo human colon carcinoma and B16 mouse melanoma sublines), resistance to Dx was induced in vitro, while in the third pair (9229 human metastatic melanoma clones), Dx resistance w...

Notch (N) signaling is an evolutionarily conserved mechanism that regulates many cell-fate decisions. deltex (dx) encodes an E3-ubiquitin ligase that binds to the intracellular domain of N and positively regulates N signaling. However, the precise mechanism of Dx action is unknown. Here, we found that Dx was required and sufficient to activate the expression of gene targets of the canonical Su(...

In order to elucidate the biochemical mechanism by which doxorubicin (DX) induces cumulative dose-dependent cardiomyopathy, the effect of DX on beating and on lipid peroxide level in myocardial cells was investigated by using a mouse myocardial cell culture system. Inhibition by DX of the beating of cultured myocardial cells was doseand exposure timedependent. When incubated with DX for 0.5 h, ...

in this paper, using a generalized dunkl translation operator, we obtain an analog of titchmarsh's theorem for the dunkl transform for functions satisfying the lipschitz-dunkl condition in $mathrm{l}_{2,alpha}=mathrm{l}_{alpha}^{2}(mathbb{r})=mathrm{l}^{2}(mathbb{r}, |x|^{2alpha+1}dx), alpha>frac{-1}{2}$.

The vacuum solution ds = dx + x dy + 2 dz dt + lnx dt of the Einstein gravitational field equation follows from the general ansatz ds = dx + gαβ(x) dx dx but fails to follow from it if the symmetric matrix gαβ(x) is assumed to be in diagonal form. KEY: Vacuum solution, Einstein field equation, symmetries, diagonalization

The sensitivity of three different human and murine doxonibicin (Dx)sensitive or -resistant pairs of tumor cells to recombinant interleukin 2 (rii,2)-aclivaled lymphocytes was studied. In two pairs of these sublines (LoVo human colon carcinoma and B16 mouse melanoma sublines), resistance to Dx was induced in vitro, while in the third pair (9229 human metastatic melanoma clones), Dx resistance w...