Aschenbach, William G., Richard C. Ho, Kei Sakamoto, Nobuharu Fujii, Yangfeng Li, Young-Bum Kim, Michael F. Hirshman, and Laurie J. Goodyear. Regulation of Dishevelled and -catenin in rat skeletal muscle: an alternative exercise-induced GSK-3 signaling pathway. Am J Physiol Endocrinol Metab 291: E152–E158, 2006. First published February 14, 2006; doi:10.1152/ajpendo.00180.2005.— catenin is a mu...

Survey class Autonomous Underwater Vehicles (AUVs) typically rely on Doppler Velocity Logs (DVL) for precise navigation near the seafloor. In cases where the distance to the seafloor is greater than the DVL bottom lock range, localizing between the surface where GPS is available and the seafloor presents a localization problem, since both GPS and DVL are unavailable in the mid-water column. Pre...

Wnt signaling pathways are involved in embryonic development and adult tissue maintenance and have been implicated in tumorigenesis. Dishevelled (Dvl/Dsh) protein is one of key components in Wnt signaling and plays essential roles in regulating these pathways through protein-protein interactions. Identifying and characterizing Dvl-binding proteins are key steps toward understanding biological f...

The dishevelled (Dvl) PDZ domain is believed to play an essential role in the canonical and noncanonical Wnt signaling pathways, which are involved in embryo development as well as in tumorigenesis. Also, it binds directly to frizzled (Fz) receptors. An organic molecule (NSC668036) from the National Cancer Institute small-molecule library has been identified to be able to bind to the Dvl PDZ do...

The carboxy (C)-termini of G protein coupled receptors (GPCR) dictate essential functions. The KTXXXW motif C-terminus of Frizzleds (FZD) has been implicated in recruitment of Dishevelled (DVL). Through study of FZD4 and its associated ligand Norrin, we report that a minimum of three residues distal to the KTXXXW motif in the C-terminal tail of Frizzled-4 are essential for DVL recruitment and r...

This paper proposes a real-time navigation system for an AUV that takes advantage of the complementary performance of a sensor suite including a DVL, a compass, a depth sensor and altimeter sensors with a feature based motion estimator using vision. To allow for real-time performance of the vision based motion estimator a simple but fast correlation algorithm is used for feature matching. The c...

Astrocytomas are the most common form of primary brain tumors. Understanding the molecular basis of development and progression of astrocytomas is required to develop more effective therapies. Although, over activation of Wnt/beta-catenin/Tcf pathway is a hallmark of several forms of cancer, little is known about its role in human astrocytomas. Here, we report the evidence that Wnt/beta-catenin...

Dishevelled (DVL) proteins, three of which have been identified in humans, are highly conserved components of canonical and noncanonical Wnt signaling pathways. These multifunctional proteins, originally discovered in the fruit fly, through their different domains mediate complex signal transduction: DIX (dishevelled, axin) and PDZ (postsynaptic density 95, discs large, zonula occludens-1) doma...