We previously reported a functional defect of von Willebrand factor (vWF) in a new variant of von Willebrand disease (vWD) tentatively named vWD "Normandy." The present work has attempted to characterize the molecular abnormality of this vWF that fails to bind factor VIII (FVIII). The immunopurified vWF from normal and patient's plasma were digested by trypsin and the resulting peptides were co...

Starting from Hendricks and McAfee's (2000) example of the Allies' decision to feint at Calais and attack at Normandy on D-Day, this paper models misrepresentation of intentions to competitors or enemies. Allowing for the possibility of bounded strategic rationality and rational players' responses to it yields a sensible account of lying via costless, noiseless messages. In many cases the model...

Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27705, USA Center for Human Genome Variation, Duke University School of Medicine, Durham, NC 27708, USA Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA Dr. John T. Macdonald Foundation Department of Human G...

Author details Center for Health Services Research in Primary Care, Durham Veterans Affairs Medical Center, Durham, NC, USA. Department of Medicine, Division of General Internal Medicine, Duke University Medical Center, 411 W. Chapel Hill Street; Suite 500, Durham, NC 27701, USA. Duke University School of Nursing, Durham, NC, USA. Duke Clinical Research Institute, Durham, NC, USA. Duke Universi...

The instinct to innovate has long been a part of Duke University Health System’s organizational DNA. Ahead of the curve in the healthcare industry, Duke recognized the need for a new level of patient engagement for healthcare transformation initiatives to achieve their full potential. What makes such engagement possible is a deep personalization capability enabled by powerful healthcare analyti...

Special classes of asynchronous e-learning systems are the intelligent tutoring systems which represent an advanced learning and teaching environment adaptable to individual student’s characteristics. Authoring shells have an environment that enables development of the intelligent tutoring systems. In this paper we present, in entirety, for the first time, our approach to research, development ...

behalf of Duke University School of Medicine Department of Psychiatry, Duke University Medical Center, Durham, North Carolina; Trent Center for Bioethics, Humanities, and History of Medicine, Duke University School of Medicine, Durham, North Carolina Address correspondence to Rachel A. Bowman, PhD, Durham Child Development and Behavioral Health Clinic, Duke University School of Medicine, 402 Tr...

From the Duke Clinical Research Institute, Duke University, Durham, NC (M.R.P., E.D.P., D.D., J.M.B., P.S.D.); University of California at San Francisco, San Francisco (R.F.R., R.G.B.); and the University of Texas Health Science Center, Houston (H.V.A.). Address reprint requests to Dr. Patel at the Duke Clinical Research Institute, Duke University Medical Center, P.O. Box 17969, Durham, NC 2771...

Starting from an example of the Allies’ decision to feint at Calais and attack Normandy on D-Day, this paper models misrepresentation of intentions to competitors or enemies. Allowing for the possibility of bounded strategic rationality and rational players’ responses to it yields a sensible account of lying via costless, noiseless messages. In some leading cases, the model has generically uniq...