Lipids are indispensable cellular building blocks, and their post-translational attachment to proteins makes them important regulators of many biological processes. Dysfunction protein lipidation is also implicated in pathological states, yet its systematic analysis presents significant challenges. Thanks innovations chemical proteomics, can now be readily studied by metabolic tagging using fun...

Pseudokinases, the catalytically impaired component of the kinome, have recently been found to share more properties with active kinases than previously thought. In many pseudokinases, ATP binding and even some activity is preserved, highlighting these proteins as potential drug targets. In both active kinases and pseudokinases, binding of ATP or drugs in the nucleotide-binding pocket can stabi...

Novel therapeutics in areas with a high unmet medical need are based on innovative drug targets. Although 'biologicals' have enlarged the space of druggable molecules, the number of appropriate drug targets is still limited. Discovering and assessing the potential therapeutic benefit of a drug target is based not only on experimental, mechanistic and pharmacological studies but also on a theore...

Hypothetical proteins often with unknown functions . Mycobacterium tuberculosis H37Rv has a very large number of such proteins , which can be exploited as drug target as the bacterium became more virulent with developing antibiotic resistance to first line and second line of drugs . Some hypothetical proteins (290 proteins) were studied from different aspects related to find the druggable prote...

An increasing number of laboratories that focus on model systems are considering drug screening. Executing a drug screen is complicated enough. But the path for moving initial hits towards the clinic requires a different knowledge base and even a different mindset. In this Editorial I discuss the importance of doing some homework before you start screening. 'Lead hits', 'patentable chemical spa...