BACKGROUND Emergence of human immunodeficiency virus type 1 (HIV-1) drug resistance may limit the benefits of antiretroviral therapy in resource-limited settings. The prevalence of resistance was assessed among patients from KwaZulu Natal, South Africa, following failure of their first highly active antiretroviral therapy (HAART) regimen. METHODS Genotypic resistance testing was performed on ...

objective: the use of antiretroviral drugs has proven remarkably effective in controlling the progression of human immunodeficiency virus (hiv) disease, but these benefits can be compromised by the development of drug resistance. this study aims to assess the drug resistance profile of the pr gene in highly active antiretroviral therapy (haart)-treated and naïve hiv-1 infected patients. metho...

objectives in this study, we explored a physical method of converting drug-resistant bacteria to drug-sensitive ones. materials and methods this is an in vitro case-control study, performed at the ionizing and non-ionizing radiation protection research center (inirprc), shiraz university of medical sciences (sums), shiraz, iran in 2014. all experiments were carried out using gram-negative bacte...

conclusions these findings underscored the importance of monitoring and developing guidelines for better management of infectious diarrhoea in bangladesh and elsewhere. background diarrhoea is considered as the most widespread illness occurring in bangladesh. in addition, the growing antimicrobial resistance of diarrhoeal pathogens in this developing country hardens physicians to supervise pati...

BACKGROUND While the high burden of multidrug-resistant tuberculosis (MDR-TB) itself is a matter of great concern, the emergence and rise of advanced forms of drug-resistance such as extensively drug-resistant TB (XDR-TB) and extremely drug-resistant TB (XXDR-TB) is more troubling. The aim of this study was to investigate the trends over time of patterns of drug resistance in a sample of MDR-TB...

The potentially pathogenic Non-Tuberculosis Mycobacteria (NTM) are emerging nowadays which result in pulmonary and non-pulmonary infections in human. This group of bacteria consists of at least 200 different species. While the pulmonary disease is the most common form of NTM infections, NTM can cause diffused infections as well as extrapulmonary infections in every organ, such as bone marrow, s...

conclusions with regards to the continuous changing in causative microorganisms isolated from patients with uti and antibiotic sensitivity patterns, it is recommended that bacterial sensitivity patterns in populations are determined in any region annually. . objectives this study aimed to detect and also compare the frequency and drug resistance pattern of gram negative bacteria isolated from p...

background: nosocomial infections are one of the most important medical problems in developed and under developing countries which cause the spread of infections diseases in society. pseudomonas aeroginosa is one of the most important causes of hospital infections, especially in wounds from operated patients. increase in antibiotic-resistance of pseudomonas aeroginosa cause a lot of problems fo...

Interpreting the results of plasma human immunodeficiency virus type 1 (HIV-1) genotypic drug-resistance tests is one of the most difficult tasks facing clinicians caring for HIV-1-infected patients. There are many drug-resistance mutations, and they arise in complex patterns that cause varying levels of drug resistance. In addition, HIV-1 exists in vivo as a virus population containing many ge...

extensively drug-resistant tuberculosis (xdr-tb) is a new challenge for tuberculosis control programs. lack of effective drugs and high rate of failure in treatment and mortality is a major threat for public health. treatment of this serious infection needs well-designed individualized dosage regimen and powerful national tb program. in this review we will describe the xdr-tb definition and its...