INTRODUCTION .......................................................................................................................................................564 Brief History ............................................................................................................................................................565 MAJOR GROUPS OF ANTIMICROBIAL COMPOUNDS FROM PLANTS ......

Currently, there is a growing interest in the study of natural products, especially as part of drug discovery programs. Secondary metabolites can be extracted from a variety of natural sources, including plants, microbes, marine animals, insects, and amphibia. This chapter focuses principally on laboratory-scale processes of initial and bulk extraction of natural products from plant and microbi...

Background and objectives: There is a growing trend towards investigating natural products as sources of compounds with biological effects and many researches have been carried out in order to find effective medications against many diseases. Cancer is no exception and studies focusing on evaluating the effects of different materials on DNA, give valuable information in cancer researches and ca...

Secondary plant metabolites reveal numerous biological activities making them attractive as resource for drug development of human diseases. As the majority of cancer drugs clinically established during the past half century is derived from nature, cancer researchers worldwide try to identify novel natural products as lead compounds for cancer therapy. Natural products are considered as promisi...

BACKGROUND Nature has been a source of medicinal products for millennia, with many useful drugs developed from plant sources. Following discovery of the penicillins, drug discovery from microbial sources occurred and diving techniques in the 1970s opened the seas. Combinatorial chemistry (late 1980s), shifted the focus of drug discovery efforts from Nature to the laboratory bench. SCOPE OF RE...

Plants have long served as traditional herbal medicines, and natural products make excellent leads for new drug development. New plant-derived medicines can come from three sources: single active principles, active fractions, and validated prescriptions. Conventionally, for single active compounds, lead discovery and drug development involve highly efficient bioactivity-directed fractionation a...

Monsonia (Monsonia burkeana Planch. ex Harv) is one of the most valuable tea and traditional medicinal plants used in Southern Africa. In spite of this, there is no sequence information regarding this plant in literature. To provide understanding of the naturally occurring tea and drug-specific products and the key pathways for the biosynthesis of these molecules, we sequenced the leaf transcri...

Plant and plant products are the major source for the discovery of new drugs. Alangium salviifolium utilized in traditional medicine has resourceful medicinal properties.The aim of present study was to evaluate the biological activity of alkaloid β Carboline harmaline of Alangium salviifolium in cell growth activity inhibition. The potentiality of the alkaloid compound in inhibition of MTHFR wi...

The global scenario is now supporting the development of modern drugs from less toxic plant products with proven medicinal properties. Each part of neem plant [Azadirachta indica A. Juss] reportedly have various medicinal properties and has been in use in many continents for centuries. Recently, a fractionated neem-leaf extract known as IRAB with reported activities against Malaria, HIV/AIDS an...