نتایج جستجو برای: drug metabolism
تعداد نتایج: 792396 فیلتر نتایج به سال:
Variations in drug metabolism may alter drug efficacy and cause toxicity; better understanding of the mechanisms and risks shall help to practice precision medicine. At the 21st International Symposium on Microsomes and Drug Oxidations held in Davis, California, USA, in October 2-6, 2016, a number of speakers reported some new findings and ongoing studies on the regulation mechanisms behind var...
the aim of the present study was to develop and investigate the feasibility of delivering nebivolol as a transdermal patch by iontophoresis. the passive and electrically assisted transdermal delivery of nebivolol hydrochloride by iontophoresis will improve the therapeutic efficacy and overcome the difficulties raised in oral drug delivery. because of its extensive hepatic metabolism and low dos...
Adjustment of phenytoin dosage in patients is very difficult due to its nonlinear metabolism and patient to patient variation in its kinetics. It has been recommended that the dosage of phenytoin should be adjusted according to its plasma concentration and requirements of the patients. Therefore, the present study was carried out to identify the various factors which may influence the plas...
Purposes: Propranolol HCl is a beta blocker commonly used worldwide; however, it shows a low bioavailability due to its extensive first-pass metabolism. To solve this problem, a novel drug delivery system such as buccoadhesive system might be helpful. The aim of the present investigation is to prepare the buccoadhesive tablet of propranolol HCl using different mucoadhesive polymers. Method: Buc...
Sodium-glucose cotransporter 2 inhibitor (SGLT2i) is a new type of hypoglycemic drug, which can reduce the excitability sympathetic nerve by regulating metabolism energy substrate, electrolyte, tissue fluid and circulating blood volume in ganglion, interfering with inflammation oxidative stress, offering protection to vascular endothelial cells, maintaining vasodilation function, pressure load ...
Purposes: Propranolol HCl is a beta blocker commonly used worldwide; however, it shows a low bioavailability due to its extensive first-pass metabolism. To solve this problem, a novel drug delivery system such as buccoadhesive system might be helpful. The aim of the present investigation is to prepare the buccoadhesive tablet of propranolol HCl using different mucoadhesive polymers. Method: Buc...
Orally delivered small-molecule therapeutics are metabolized in the liver and intestine by phase I and phase II drug-metabolizing enzymes (DMEs), and transport proteins coordinate drug influx (phase 0) and drug/drug-metabolite efflux (phase III). Genes involved in drug metabolism and disposition are induced by xenobiotic-activated nuclear receptors (NRs), i.e. PXR (pregnane X receptor) and CAR ...
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