Childhood is a time filled with wondrous changes, as brain plasticity permits experiences to shape the immature brain to meet the demands of the environment. Change occurs at various levels--from neuroanatomy, including within a given region and its connectivity to other regions, to the function of neurotransmitter systems and their reactivity to pharmacological agents in the short- and long-te...

The article is devoted to an experimental study determine the toxicological safety profile of anti-tuberculosis drug «Rifabutin» with prolonged exposure animals

Background Whether arrhythmia risks will increase if drugs with electrocardiographic (ECG) QT-prolonging properties are combined is generally supposed but not well studied. Based on available evidence, the Arizona Center for Education and Research on Therapeutics (AZCERT) classification defines the risk of QT prolongation for exposure to single drugs. We aimed to investigate how combining AZCER...

among the numerous nanosized drug delivery systems currently under investigation, carbon nanotubes (cnts), regardless of being single or multiple-walled, offer several advantages and are considered as promising candidates for drug targeting. despite the valuable potentials of cnts in drug delivery, their toxicity still remains an important issue. after the pegylation of single-walled cnts (swcn...

The following pages represent a summary of many articles, papers, reviews and books on medications and the CNS function, and finally nearly 30 years of experience in clinical and research EEG. The difficulty in this area is the definitions of bands varies, the methods of analysis range from visual inspection of the raw EEG to quantitative measures, not all of which are clearly defined... and th...

This manuscript provides an overview of the current scientific literature on the impact of maternal drug use, specifically opioids and cocaine, during pregnancy on the acute and long-term outcomes of infants and toddlers from birth through age 3 years. Emphasis with regard to opioids is placed on heroin and opioid substitutes used to treat opioid addiction, including methadone, which has long b...

The polydrug pattern of drug use by pregnant women, combined with the varying purity, dosage, and timing during pregnancy when drugs are taken, makes it very difficult to determine the developmental impact of any specific drug. Nevertheless, studies of drug-exposed newborns suggest an array of behavioral characteristics that make their care challenging, and a few studies indicate that some pren...

NIDA Research Monographs are prepared by the research divisions of the National Institute on Drug Abuse and published by its Office of Science. The primary objective of the series Is to provide critical reviews of research problem areas and techniques, the content of state-of-the-art conferences, and integra-tive research review. Its dual publication emphosis is rapid and targeted dissemination...