BACKGROUND Increasing recognition of the burden associated with iatrogenic disease has led to international interest into how best to promote patient safety. Within this field, the subject of adverse drug events (ADEs) has received particular attention, this reflecting the known high frequency with which such events occur, particularly in the elderly. METHODS We conducted a narrative review s...

Many therapeutic drugs have been associated with hematologic adverse drug events (ADEs) in animals. Some drugs, notably chemotherapeutic agents and oxidant compounds, cause dose-dependent bone marrow suppression, while others induce idiosyncratic ADEs. Major mechanisms associated with ADEs include immuneor oxidant-mediated destruction of blood cells and toxic bone marrow injury. General classes...

The first general anaesthetics resulted from the action of one drug, either ether or chloroform. Today, general anaesthetics are usually complex "cocktails" and it is not uncommon for several different drugs to be given. Each of these has a distinct, predictable pharmacological action. Thus, when an unpredicted reaction occurs shortly after the injection of a drug, one possible explanation is t...

objective: addiction is one of the most vulnerable social issues and the tendency to it involve several factors, including psychosocial stressors (life unpleasant events), and inability to deal with these stressors and the belief that drug use will lead to the desired result. this study was conducted to determine the relationship between psychosocial stressors and vulnerability to drug abuse am...

OBJECTIVE To determine rates and types of adverse drug events (ADEs) in the pediatric ambulatory setting. METHODS A prospective cohort study at 6 office practices in the greater Boston area was conducted over 2-month periods. Duplicate prescription review, telephone surveys 10 days and 2 months after visit, and chart reviews were done. A 2-physician panel classified the severity, preventabili...

The pharmaceutical industry, consumer protection groups, users of medications and government oversight agencies are all strongly interested in identifying adverse reactions to drugs. While a clinical trial of a drug may use only a thousand patients, once a drug is released on the market it may be taken by millions of patients. As a result, in many cases adverse drug events (ADEs) are observed i...

Illicit drug abuse continues to be a growing problem worldwide and a serious hazard to humanity. The crimes associated with drug abuse include sale or possession of drugs; property crimes or prostitution to support drug habits; and violent crimes reflecting out-of-control behavior. In fact, an offender drug use is involved in more than half of all violent crimes and in 60 to 80 percent of child...