Density functional theory (DFT) calculations were performed on tripeptide arginyl-glycyl-aspartic acid (RGD) as an efficient drug carrier to deliver the commercially famous cyclophosphamide (CP) anticancer drug within ethanol solution. The most negative binding energy (-5.22 kcal/mol) was measured for the CP-RGD-7 created through the H-bond interaction between the P=O (phosphoryl) oxygen atom o...

Microscopic Cascading Devices In article number 2206330, Tijana Maric and co-workers present cascade drug delivery microdevices comprise of micromotors microcontainers to deliver a model move through porcine mucosa. The conceptual device combines the advantages unidirectional release achieved by orientation dynamic motion properties micromotors.

In this paper we show that controlling adhesion in highly flexible nanovectors can help in smartly delivering the drug. The high flexibility of the nanovector is used to smartly deliver the drug only at the target site by the new concept of "adhesion induced nanovector implosion"; a liquid drop analogy is developed for the calculations.

Drug delivery to the skin is limited by the strong barrier properties of skin's outer layer of stratum corneum. Micron-scale needles have been developed to deliver drugs across this barrier layer and into the skin in a minimally invasive manner. One method of delivery involves coating these microneedles with a drug that rapidly dissolves off within the skin. As a variation on this approach, thi...

A sperm-driven micromotor is presented as a targeted drug delivery system, which is appealing to potentially treat diseases in the female reproductive tract. This system is demonstrated to be an efficient drug delivery vehicle by first loading a motile sperm cell with an anticancer drug (doxorubicin hydrochloride), guiding it magnetically, to an in vitro cultured tumor spheroid, and finally fre...