In the present investigation an attempt has been made to increase therapeutic efficacy, to reduce frequency of administration and to improve patient compliance by developing a sustained release matrix tablets of isosorbide-5-mononitrate. Sustained release matrix tablets of isosorbide-5-mononitrate were developed by using different drug: polymer ratios, such in F1 (1:0.75), F2 (1:1), F3 (1:1.5),...

Failure to comply with drug regimes is prevalent amongst patients with epilepsy and the consequence of this is often an increased risk of further seizures. This paper describes the level of, and influences upon, non-compliance with antiepileptic drug (AED) treatment. A postal questionnaire was sent to an unselected, community-based population of patients with epilepsy. This instrument included ...

Contingency management (CM) procedures, that provide incentives for specific behaviors, are efficacious in treating substance use disorders. Typically, CM interventions reinforce submission of urine specimens negative for the targeted drug(s) of abuse, but other behaviors can be reinforced as well, such as compliance with non-drug-related activities. This article describes 1,059 activities chos...

The recent increase in the notifications of tuberculosis infections has focused the attention of healthcare professionals on reasons for the disease's resurgence. This article describes how directly observed therapy and an enlightened approach to health promotion for groups of people perceived as being at risk, could prevent further increases in incidence.

AIMS Multi-drug resistant Plasmodium falciparum malaria is a rapidly increasing problem in the world, particularly Thailand. Practical antimalarial regimens which are highly effective against multi-drug resistant parasites with short-term course of administration are needed. In this study, we assessed the patient compliance of a short course regimen using artemether-mefloquine. METHODS Clinic...

OBJECTIVES 1) To evaluate the compliance with drug treatment in patients with metabolic syndrome. 2) To determine association between access to and use of medicines, as well as the level of knowledge of cardiovascular risk factors and compliance. INTRODUCTION Low compliance has been one of the greatest challenges for the successful treatment of chronic diseases. Although this issue has been w...

Special Issue Tsipi Heart Ben-Gurion University of the Negev [email protected] Yisrael Parmet Ben-Gurion University of the Negev [email protected] Nava Pliskin Ben-Gurion University of the Negev [email protected] The objective of this study was to investigate physicians' compliance with recommendations for drug substitutes embedded within an electronic medical record, to assess factors affecting...

The treatment for tuberculosis is a combination of strong antibiotics that must be taken daily for at least 6 months. But side-effects, such as nausea and heartburn, dissuade some patients from sticking with the treatment. Other patients endure the side-effects only to drop the medication once they feel better 1 or 2 months into the regimen. The Stop TB Partnership reports that on average 5% of...

OBJECTIVE To characterize the factors that interfere in drug treatment compliance in a group of individuals with arterial hypertension. METHODS A non-experimental descriptive study that analyzed a sample of 80 patients diagnosed with arterial hypertension, who underwent medical treatment and were admitted to a university hospital during the period from March to May 2009. To collect data, the ...

A 62-year-old Caucasian woman underwent evaluation for possible liver transplantation. She had endstage cirrhosis secondary to hepatitis C and alcohol abuse. Among the tests ordered were urine screens for various drugs of abuse, including amphetamines, for which the patient’s urine sample was positive. Given the patient’s history of alcohol abuse and possible other drug abuse, her physicians qu...