conclusions it seems that tertiary amine drugs such as amitriptyline and doxepin had reasonable potencies of spinal blockade when compared to bupivacaine. however, amitriptyline had a more potent and long-acting spinal anesthetic effect. amitriptyline may turn out to be a clinically valuable local anesthetic. results in groups 1 and 2, a total of 3 rats died. after adjusting the concentrations,...

GENERIC NAME PAGE Amitriptyline 389 Amoxapine 389 Bupropion 388 Carbamazepine 395 Citalopram 388 Clomipramine 389 Desipramine 389 Doxepin 389 Fluoxetine 387 Fluvoxamine 386 Imipramine 389 Isocarboxazid 392 Lithium 393 Maprotiline 389 GENERIC NAME PAGE Mirtazapine 388 Nefazodone 389 Nortriptyline 389 Olanzapine 395 Paroxetine 388 Phenelzine 392 Protriptyline 389 Sertraline 387 Tranylcypromine 39...

The selection of a starting dose for an antidepressant, and subsequent clinical titration to an appropriate therapeutic dosage, should be based on pharmacokinetic and pharmacodynamic principles. In the past decade, therapeutic monitoring of antidepressant drugs and use of pharmacokinetic principles have been shown to be an improvement over the dose-response approach. Endogenous (e.g., genetic m...

Clinical observation on treatment of dysthymia with combined use of Xiaochaihu Decoction and doxepin ZHANG Xue-Zhen, LI Zhen-Jiang ( 1 . Department of Psychology , Baoding Second Hospital , Hebei Province 071051 , China; 2 . Department of Internal Medicine , Baoding First Hospital of Traditional Chinese Medicine , Hebei Province 071000 , China )

Thermoreversible biogels can serve as effective systems for delivery of drugs through nose with increased nasal residence time. The objective of this study was to use chitosan and glycerophosphate based thermoreversible systems for delivery of doxepin to brain through intranasal administration. Formulations were prepared by admixture of suitable dilutions of chitosan and glycerophosphate with o...