This paper presents Cache Digest, a novel protocol and optimization technique for cooperative Web caching. Cache Digest allows proxies to make information about their cache contents available to peers in a compact form. A peer uses digests to identify neighbors that are likely to have a given document. Cache Digest is a promising alternative to traditional per-request query/reply schemes such a...

A fundamental problem in computational biology is the construction of physical maps of chromosomes from the hybridization experiments between unique probes and clones of chromosome fragments. Double and partial digest problems are two intractable problems used to construct physical maps of DNA molecules in bioinformatics. Several approaches, including exponential algorithms and heuristic algori...

SUMMARY A database for simulation of double digest selective label (DDSL) typing technique has been created and validated against a sequenced strain (Salmonella enterica serovar Typhimurium strain LT2). In silico bands were in agreement with experimental, and the technique was able to discriminate among strains belonging to the same species. When compared with other strain discrimination techni...

An essential step in embedded software development, floatingto fixed-point conversion can be tedious, labor-intensive, and error-prone. System engineers frequently design algorithms in floating-point math, usually double-precision. This format represents the ideal algorithm behavior but takes little account of the algorithm’s final realization in production software and hardware. Software engin...

We have identified, in extracts from Xenopus laevis germinal vesicles, a 5' exonuclease activity that cleaves double-stranded RNA (dsRNA). Features of the 5' ends of dsRNAs determine whether the strands are symmetrically or asymmetrically degraded. The activity hydrolyzes in the 5' to 3' direction, releasing 5'-mononucleotides processively, favoring strands with 5'-monophosphate termini; molecu...

BNPS-skatole (3-bromo-3-methyl-2-(2-nitrophenyl)thiol-3H-indole) and N-bromosuccinimide have been used to specifically cleave at peptide bonds after amino acids with available C-gamma=C-delta double bonds, i.e. tryptophan, tyrosine and histidine. The resulting C-terminal lactones conveniently attach to amino-glass supports for sequencing with DABITC (4-NN-dimethylaminoazobenzene 4'-isothiocyana...

Consent in surgery. Wheeler R Ann R Coll Surg Engl. 2006 May;88(3):261-4. A review of consent for surgery is timely. As the length of surgeons' training diminishes, despite the increasing interest in the content of the surgical curriculum, the law governing the process of gaining consent has been given scant attention. The advent of non-medically qualified surgical practitioners raises question...

Welcome to the third CELMR Research Digest! We have had an excellent reception to the first two editions and are pleased to bring you further highlights of some of the recent papers and projects authored by faculty and students associated with CELMR. As always, we intend that the summaries will be as nontechnical as possible to allow for the widest dissemination of the ideas and findings from C...