Our aim was to evaluate the short and long term efficacy of botulinum toxin therapy in Iranian patients with achalasia. In a randomized, double blind trial, 20 patients with achalasia, referring to Imam Khomeini Hospital, received either 80 units of botulinum toxin (BT) or placebo (PL) from 1995 to 1998. Two weeks later, the response to treatment was assessed on the basis of changes in the...

Negative symptoms are still a major obstacle in the recovery of schizophrenic patients. Many attempts to develop novel drugs affecting negative symptoms of schizophrenia have yielded insignificant results. This study evaluates the effects of bromocriptine, a dopamine agonist, on negative symptoms of schizophrenia utilizing a placebo-controlled crossover double-blind clinical trial. Methodology:...

Title:Randomised, double-blind, placebo-controlled clinical trial of the effects of L-ornithine on stress markers and sleep quality in healthy workers

BACKGROUND Attention-deficit hyperactivity disorder is an early-onset, clinically heterogenous disorder of inattention, hyperactivity, and impulsiveness. The diagnosis and treatment of attention-deficit hyperactivity disorder continues to raise controversy, and, there is also an increase in treatment options. In this 6-week double blind, placebo controlled-trial, we assessed the effects of zinc...

conclusion it can be concluded that prophylactic antibiotics do not have any preventive effect on wound infection in a double blind setting. according to our findings, routine antibiotic prophylaxis as recommended for biliary surgery (open or laparoscopic cholecystectomy) is now questionable. results the study population included 61 males and 69 females with the mean age of 49.3±9.6 and 51.8±9....

our aim was to evaluate the short and long term efficacy of botulinum toxin therapy in iranian patients with achalasia. in a randomized, double blind trial, 20 patients with achalasia, referring to imam khomeini hospital, received either 80 units of botulinum toxin (bt) or placebo (pl) from 1995 to 1998. two weeks later, the response to treatment was assessed on the basis of changes in the symp...

The feature of being “double blind”, where neither patients nor physicians are aware of who receives the experimental treatment, is almost universally trumpeted as being a virtue of clinical trials. Hence, trials that fail to remain successfully double blind are regarded as providing inferior evidential support. The rationale for this view is unobjectionable: double blinding rules out the poten...

Background Dietary treatment containing fiber-rich foods may contribute to lowering weight in obese women. Objective To investigate the effect of a hypoenergetic diet combined with pumpkin seed flour (PSF) consumption on quality, anthropometric indices, and glucose lipid metabolism Methods We conducted randomized, double-blind, placebo-controlled, 90-day clinical trial women, distributed into f...

A double blind trial of a single 40 mg dose of the beta adrenergic blocking agent propranolol in the treatment of essential tremor produced significant reduction of tremor in four of five patients, but this effect was transient and had considerably diminished within four hours. A month's double blind clinical trial of propranolol, in a dose of 30 mg three times a day, showed that the active dru...

Aurora SK, Dodick DW, Turkel CC, et al.: OnabotulinumtoxinA for treatment of chronic migraine: results from the doubleblind, randomized, placebo-controlled phase of the PREEMPT 1 trial. Cephalalgia 2010, 30: 793–803. Diener HC, Dodick DW, Aurora SK, et al.: OnabotulinumtoxinA for treatment of chronic migraine: results from the double-blind, randomized, placebo-controlled phase of the PREEMPT 2 ...