The current methods for treatment of cancers are inadequate and more specific methods such as gene therapy are in progress. Among different vehicles, cationic liposomes are frequently used for delivery of genetic material. This investigation aims to prepare and optimize DOTAP cationic liposomes containing an antisense oligonuclotide (AsODN) against protein kinase C alpha in non-small cells lung...

Oligonucleotides able to hybridize bacterial RNA via in situ hybridization may potentially act as new antimicrobials, replacing antibiotics, and fast vivo diagnostic probes, outperforming current clinical methodologies. Nonetheless, oligonucleotides are not efficiently permeate the multi-layered envelope reach their target cytosol. Cationic fusogenic liposomes here suggested vehicles enable int...

objective(s):the objective of this study was to determine the cytotoxic effects of nanoliposomal form of lyophilized aqueous extract of agrostemma githago (a. githago) seeds on gastric cancer cell line (ags) using cell viability tests. materials and methods: lyophilized aqueous extract of a. githago seeds was prepared. liposomes were also prepared by thin-film hydration method and their stabili...

liposomes have attracted great interest as efficient carriers for nutrients, drugs and other bioactive agents as well as ideal models for biological membranes. this article intends to provide an overview of liposomes and nanoliposomes definition as well as their properties and preparation methods. also it elaborates on various applications of nanoliposomes in nanotherapy including diagnostics, ...

Delivery of oligonucleotides has been a major impediment in the development of nucleic acid based drugs. In this report, we show that neomycin, an aminoglycoside antibiotic, when combined with a cationic lipid preparation such as DOTAP, enhances transfection efficiency of both reporter plasmids and oligonucleotides and results in a significant increase in transgene expression. The results descr...

BACKGROUND Recent reports that TLR4 and TLR7 ligands can synergistically trigger Th1 biased immune responses suggest that an adjuvant that contains both ligands would be an excellent candidate for co-administration with vaccine antigens for which heavily Th1 biased responses are desired. Ligands of each of these TLRs generally have disparate biochemical properties, however, and straightforward ...

Background: Glioblastoma (GBM) is one of the most aggressive tumors, health-threatening, and resistant to available treatment approaches for people worldwide. Objectives: This study aimed evaluate effects swimming training a supplement comprising four nanoliposome herbal extracts in rat model with mid-brain tumor. Methods: In this experimental study, 56-male-Wistar rats (230 ± 20 g) were divide...