Normal cellular models able to efficiently recapitulate intestinal epithelial cell differentiation in culture are not yet available. The aim of this work was to establish and genetically characterize a mesenchymal-epithelial coculture system to identify transcriptional regulators involved in this process. The deposition of rat intestinal epithelial cells on human intestinal mesenchymal cells le...

This study proposed a framework of optimal design for flexible cable dome structures based on progressive collapse resistance. First, quantitative evaluation method nonlinear robustness control theory to reflect the structural resistance was proposed. Second, an actual engineering structure used as case evaluate effects parameters robustness. Finally, genetic algorithm optimisation further opti...

The design of future large optical telescopes must take into account the wind-induced buffeting of the telescope structure caused by large-scale flow structures and turbulence inside the dome. However, estimating the resulting degradation in image quality is difficult due to our relatively poor understanding of the flow inside the dome. Data has been collected in a scaled wind-tunnel test of a ...

ESCRT-III proteins catalyze membrane fission during multi vesicular body biogenesis, budding of some enveloped viruses and cell division. We suggest and analyze a novel mechanism of membrane fission by the mammalian ESCRT-III subunits CHMP2 and CHMP3. We propose that the CHMP2-CHMP3 complexes self-assemble into hemi-spherical dome-like structures within the necks of the initial membrane buds ge...

Like other structures, shallow domes have imperfections from the prescribed values obtained by specifications during the construction process. Specifications define some tolerance values for imperfections. Despite consideration of these values, the critical load of a dome varies for each imperfection pattern. So the reliability plays an important role in domes safety. Theoretical evaluation pro...

urban spaces and in other words urban design and architecture have been found with close linkage with art and beauty especially the arts such as painting and sculpture. addressing beauty at different areas such as creation of galleries to offer works of art, addressing form of urban spaces and representing works of art in urban environment have improved social life and increased identity, conse...

The mild compressional structures of Cenozoic age on the passive margins bordering Norway, the UK, the Faroes and Ireland have been the subject of much discussion in the literature. Nevertheless, their origin remains enigmatic. Candidate mechanisms must be able to explain the generation of sufficient stress to cause deformation, the episodic nature of the structures and why they developed where...