As neoplasias renais correspondem ao crescimento exacerbado de células tumorais no interior dos rins, classificadas como benignas ou malignas. Neste estudo será abordado sobre as malignas renais, a qual maior prevalência e são representadas pelo carcinoma o tumor Wilms, com finalidade descrever respeito aspectos anatomopatológicos, disseminando informações para diagnóstico manejo precoce. O é m...

Retinoids, which are important regulators of cell growth, differentiation, and apoptosis, have been used in treatment or chemoprevention of multiple cancers including prostate cancer. To elucidate the mechanism of action of retinoids in the context of the prostate, we used the Cre-loxP system to disrupt the retinoid X receptor alpha (RXRalpha) gene specifically in the prostatic epithelium of th...

PURPOSE Molecular analysis of pancreatic intraepithelial neoplasia lesions and ductal adenocarcinoma suggested a multistage paradigm for pancreatic duct cell carcinogenesis. This study investigated the molecular basis for the neoplastic duct cells in this pancreatic intraepithelial neoplasia-carcinoma sequence to acquire progressive enhancement of their proliferative potential. EXPERIMENTAL D...

Retinoids, which are important regulators of cell growth, differentiation, and apoptosis, have been used in treatment or chemoprevention of multiple cancers including prostate cancer. To elucidate the mechanism of action of retinoids in the context of the prostate, we used the Cre-loxP system to disrupt the retinoid X receptor (RXR ) gene specifically in the prostatic epithelium of the mouse. E...

We present an improved area estimation model that considers the large influence of pin positions on the layout area. The estimation method is based on the shape function approach described by Zimmermann [11]. A cell is abstracted at all hierarchy levels by discrete shape func-ed at all hierarchy levels by discrete shape functions describing its area with respect to its shape. The internal wirin...