OBJECTIVES Takotsubo stress cardiomyopathy (TSC) is an increasingly recognised and diagnosed disease, although the underlying pathophysiology is still unknown. Our aim was to investigate the effect of the catecholamine dobutamine on coronary flow reserve (CFR) measured non-invasively in patients with TSC and controls. Our hypothesis was that dobutamine stress can induce microvascular dysfunctio...

The effect of i.v. dobutamine on acute myocardial ischemic injury was assessed in 22 anesthetized dogs subjected to serial 10-minute occlusions of the left anterior descending coronary artery. The severity of ischemic injury was determined by mass spectrometric measurement of the increase in intramural carbon dioxide tension (delta PmCO2) in the ischemic zone. In the time protocol 1 dogs, dobut...

OBJECTIVE To determine whether dobutamine stress echocardiography can predict the improvement of left ventricular systolic function in patients with dilated cardiomyopathy (DCM). METHODS Myocardial contractile reserve, as assessed by dobutamine stress echocardiography, was determined in 18 patients with DCM (mean (SD) age 53 (13) years, left ventricular ejection fraction (LVEF) 28 (10)%) and ...

Introduction Dobutamine is an effective pharmacologic stress agent commonly used in cardiac stress testing, but has several well documented adverse effects including serious arrhythmias and myocardial infarction. The most common dobutamine protocol is to infuse an increasing dose of 10 μg/kg followed by 20, 30, then 40 μg/kg until target HR is achieved. Atropine may be added after the 40 μg/kg ...

We report the case of a fatal intracranial hemorrhage after dobutamine stress echocardiography for chest pain in a 63-year-old female with no previous vascular risk factors. The patient experienced severe headache during stress testing and became clinically unresponsive 2-3 hours afterward. Imaging demonstrated a large 7.9 cm × 6.7 cm intracerebral hemorrhage (ICH) with subfalcine herniation. T...

AIMS This study investigated the functional outcome of wall-thinned, akinetic myocardium after revascularization and evaluated the accuracy of dobutamine echocardiography in predicting post-revascularization functional recovery with the assessment of end-diastolic wall thickness in chronic ischaemic patients. METHODS AND RESULTS Fifty-three patients underwent dobutamine echocardiography befor...

Dobutamine is the inotrope most commonly used in septic shock patients to increase cardiac output and correct hypoperfusion. Although some experimental and clinical studies have shown that dobutamine can improve systemic and regional hemodynamics, other research has found that its effects are heterogenous and unpredictable. In this review, we analyze the pharmacodynamic properties of dobutamine...

OBJECTIVE To evaluate whether the predictive value of dobutamine echocardiography for assessing contractile reserve was altered by differing patterns of regional myocardial perfusion. PATIENTS 31 consecutive patients with symptomatic congestive heart failure (left ventricular ejection fraction < 35%) caused by coronary artery disease. SETTING A district general hospital. METHODS Thallium-...

RATIONALE Induction of heme oxygenase-1 (HO-1) protects the liver against reperfusion injury after hemorrhagic shock. Previous data suggest that the beta(1)-adrenoceptor agonist dobutamine induces HO-1 in hepatocytes. OBJECTIVES To investigate the functional significance of dobutamine pretreatment for liver function after hemorrhagic shock in vivo. METHODS Anesthetized rats received either ...

OBJECTIVES This work was undertaken to define the intrinsic cardiac risk of the patient population referred for dobutamine stress perfusion imaging and to determine whether dobutamine technetium-99m ((99m)Tc)-sestamibi single-photon emission computed tomography (SPECT) imaging is capable of risk stratification in this population. BACKGROUND In animal models, dobutamine attenuates the myocardi...