نتایج جستجو برای: dna repair gene

تعداد نتایج: 1565035  

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه تهران - دانشکده علوم 1387

چکیده ندارد.

Journal: :iranian journal of radiation research 0
k. rajesha nairy depatment of studies in physics, mangalore university, mangalagangotri-574 199, india n.n. bhat radiological protection and advisory division, bhabha atomic research center, mumbai-400 085, india p. joseph depatment of studies in physics, mangalore university, mangalagangotri-574 199, india g. sanjeev depatment of studies in physics, mangalore university, mangalagangotri-574 199, india n. yerol depatment of studies in physics, mangalore university, mangalagangotri-574 199, india

background: exposure to ionizing radiation is known to induce oxidative stress followed by damage to critical biomolecules like lipids, proteins and dna through radiolysis of cellular water. since radiation has been widely used as an important tool in therapy of cancer, the detailed investigation regarding the dna damage and repair kinetics would help to predict the radiation sensitivity of cel...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1990
S C Popoff A I Spira A W Johnson B Demple

DNA damage generated by oxygen radicals includes base-free apurinic/apyrimidinic (AP) sites and strand breaks that bear deoxyribose fragments. The yeast Saccharomyces cerevisiae repairs such DNA lesions by using a single major enzyme. We have cloned the yeast structural gene (APN1) encoding this AP endonuclease/3'-repair diesterase by immunological screening of a yeast genomic DNA expression li...

Journal: :Molecular carcinogenesis 2015
Jana Slyskova Francesca Cordero Barbara Pardini Vlasta Korenkova Veronika Vymetalkova Ludovit Bielik Ludmila Vodickova Pavel Pitule Vaclav Liska Vit Martin Matejka Miroslav Levy Tomas Buchler Mikael Kubista Alessio Naccarati Pavel Vodicka

DNA repair in blood cells was observed to be suboptimal in cancer patients at diagnosis, including colorectal cancer (CRC). To explore the causality of this phenomenon, we studied the dynamics of DNA repair from diagnosis to 1 yr follow-up, and with respect to CRC treatment. Systemic CRC therapy is targeted to DNA damage induction and DNA repair is thus of interest. CRC patients were blood-samp...

Journal: :Frontiers in Plant Science 2021

Together with local chromatin structure, gene accessibility, and the presence of transcription factors, positioning is implicated in expression regulation. Although basic mechanisms are expected to be conserved eukaryotes, less known about role plant cells, mainly due lack a highly resolutive approach. In this study, we adapted use ANCHOR system perform real-time single locus detection planta ....

Journal: :Molecular and cellular biology 1995
A R Lehmann M Walicka D J Griffiths J M Murray F Z Watts S McCready A M Carr

The rad18 mutant of Schizosaccharomyces pombe is very sensitive to killing by both UV and gamma radiation. We have cloned and sequenced the rad18 gene and isolated and sequenced its homolog from Saccharomyces cerevisiae, designated RHC18. The predicted Rad18 protein has all the structural properties characteristic of the SMC family of proteins, suggesting a motor function--the first implicated ...

2016
Chao Liu Florian Rohart Peter T. Simpson Kum Kum Khanna Mark A. Ragan Kim-Anh Lê Cao

DNA repair genes and pathways that are transcriptionally dysregulated in cancer provide the first line of evidence for the altered DNA repair status in tumours, and hence have been explored intensively as a source for biomarker discovery. The molecular mechanisms underlying DNA repair dysregulation, however, have not been systematically investigated in any cancer type. In this study, we perform...

2014
Katherine A. McAllister Akeel A. Yasseen George McKerr C. S. Downes Valerie J. McKelvey-Martin

Thymidine kinase 1 (TK1) is a salvage enzyme that phosphorylates thymidine, imported from surrounding fluids, to create dTMP, which is further phosphorylated to the DNA precursor dTTP. TK1 deficiency has for a long time been known to cause increased cellular sensitivity to DNA damage. We have examined preferential strand break repair of DNA domains in TK1(+) and TK1(-) clones of the Raji cell l...

Journal: :Carcinogenesis 2012
Rémi Kazma Marie-Claude Babron Valérie Gaborieau Emmanuelle Génin Paul Brennan Rayjean J Hung John R McLaughlin Hans E Krokan Maiken B Elvestad Frank Skorpen Endre Anderssen Tõnu Vooder Kristjan Välk Andres Metspalu John K Field Mark Lathrop Alain Sarasin Simone Benhamou

Lung cancer (LC) is the leading cause of cancer-related death worldwide and tobacco smoking is the major associated risk factor. DNA repair is an important process, maintaining genome integrity and polymorphisms in DNA repair genes may contribute to susceptibility to LC. To explore the role of DNA repair genes in LC, we conducted a multilevel association study with 1655 single nucleotide polymo...

Journal: :journal of biomedical physics and engineering 0
m valizadeh tehran university of medical sciences a shirazi tehran university of medical sciencesسازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (tehran university of medical sciences) p izadi tehran university of medical sciencesسازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (tehran university of medical sciences) j tavakkoly bazzaz tehran university of medical sciencesسازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (tehran university of medical sciences) h rezaeejam tehran university of medical sciencesسازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (tehran university of medical sciences)

background: after radiation therapy (rt), some health hazards including dna damages may occur where melatonin can play a protective role due to free radical generation. on the other hand, serious accidental overexposures may occur during rt due to nuclear accidents which necessitate the need for study on exposure to high-dose radiations during treatments. objective: the aim of this study was to...

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