Radiation-induced gastrointestinal (GI) syndrome currently has no effective prophylactic or therapeutic treatment. Previous studies and our data have demonstrated the important role of p53 in acute radiation-induced GI syndrome in mice. Many cytokines, such as tumor necrosis factor-α and fibroblast growth factor (bFGF), have been found to protect against radiation-induced intestinal injury, alt...

The classical definition of lymphohematopoietic stem cells (LHSC), the most primitive progenitors of all blood cells, requires that they have the capacity for self-renewal and for the long-term production of all blood cell lineages. However, other characteristics of LHSC have been debated. Our previous data suggested that mouse LHSC are very slowly proliferating cells that generate delayed mult...

Autophagy is essentially a metabolic process, but its in vivo role in nuclear radioprotection remains unexplored. We observed that ex vivo autophagy activation reversed the proliferation inhibition, apoptosis, and DNA damage in irradiated hematopoietic cells. In vivo autophagy activation improved bone marrow cellularity following nuclear radiation exposure. In contrast, defective autophagy in t...

background: ionizing radiation induces the production of reactive oxygen species (ros), which play an important causative role in cell death. the aim of this study was to investigate the protective effects of sulfated derivatives of neutral polysaccharides extracted from auricularia auricular (snaap). materials and methods: whole blood samples from healthy donors treated with snaap at different...

background: this study has been undertaken to find out the possible radioprotective potential of the alstonia scholaris extract (ase). materials and methods: for experimental study, healthy swiss albino male mice were selected from an inbred colony and divided in four groups. group i (normal) did not receive any treatment. group ii was orally supplemented ase once daily at the dose of 100 mg/ k...