A single oral dose of flupirtine maleate, a novel analgesic agent, did not antagonize significantly the diuretic action of frusemide when compared with indomethacin and placebo in normal human volunteers.

Intravenous transfusion is resorted to in various conditions of malnutrition, hypoproteinaemia and in surgery requiring intravenous alimentation (Elman, 1952; Levy and Siller, 1942; Krishnan, 1944). Being a preparation derived from proteins, several tests for its preparation, freedom from toxicity, and antigenic reactions are laid down in the pharmacopoeia (cf. Basu, Bose and Sen, 1946; U. S. P...

Intravenous administration of garlic extract (25.9 mg/kg body weight), significantly increases urinary output in dogs, whjch was also found to be dose dependent. The pH of urine was not altered after the administration of garlic extract. Effect of intravenous administration of Furosemide (1.0 mg/kg b. wt.) was also observed for control comparison. It was found that the garlic in high doses (54....

ETHACRYNIC ACID is an unsaturated ketone derivative of phenoxyacetic acid* chemically different from other known diuretic agents.' Compounds of this general class have a significant ability to bind sulfhydryl groups in vitro. Ethacrynic acid was shown by Baer and associates2 to be highly effective as a diuretic in the dog, but not in the rat. A preliminary report from this laboratory indicated ...

ETHACRYNIC ACID is an unsaturated ketone derivative of phenoxyacetic acid* chemically different from other known diuretic agents.' Compounds of this general class have a significant ability to bind sulfhydryl groups in vitro. Ethacrynic acid was shown by Baer and associates2 to be highly effective as a diuretic in the dog, but not in the rat. A preliminary report from this laboratory indicated ...

1. The renal excretion of phosphate was studied in dogs under control conditions and during infusion of ethacrynic acid or frusemide at different levels of filtered load. 2. Both of these diuretic compounds significantly enhanced the fractional excretion of phosphate at normal and moderately decreased filtered loads, and a good correlation between fractional excretions of sodium and phosphate c...

Furosemide, a potent loop diuretic, is frequently used in different stages of acute kidney injury, but its clinical roles remain uncertain. This review summarises the pharmacology of furosemide, its potential uses and side effects, and the evidence of its efficacy. Furosemide is actively secreted by the proximal tubules into the urine before reaching its site of action at the ascending limb of ...

1 RIAMTERENE MEDICAL JOURNAL azotaemia with intermittent use of SKF 8542 suggests there is some reversible effect on renal blood-flow. The diuretic response to the combination of SKF 8542 and chlorothiazide is excellent and all patients lost their ascites. The drug was active within a few hours of administration, and, unlike spironolactone, need not be given on consecutive days to obtain a diur...