Given the large number of RNA-binding proteins and regulatory RNAs within genomes, posttranscriptional regulation may be an underappreciated aspect of cis-regulatory evolution. Here, we focus on nematode germ cells, which are known to rely heavily upon translational control to regulate meiosis and gametogenesis. GLD-1 belongs to the STAR-domain family of RNA-binding proteins, conserved througho...

Fas ligand (FasL/CD95L), a member of the tumor necrosis factor family, interacts with a specific receptor Fas, ultimately leading to cell death. Tumor expression of FasL has been proposed to aid in immune evasion through a "Fas counterattack" mechanism but has also been described as a proinflammatory factor. Here, we tested the role of FasL in a mouse model of spontaneous tumor development. We ...

Coordination of the cell cycle with developmental events is crucial for generation of tissues during development and their maintenance in adults. Defects in that coordination can shift the balance of cell fates with devastating clinical effects. Yet our understanding of the molecular mechanisms integrating core cell cycle regulators with developmental regulators remains in its infancy. This wor...

Tolerancing has great impact on the cost and quality of a product. Dimensional and geometric tolerancing are designed to ensure that products meet both designed functionality and minimum cost. The task of dimensioning and tolerancing in process planning stage is to determine the working dimensions and tolerances of the machined parts by given blueprint (B/P) specifications. A lot of research wo...

Homozygosity for either of the lymphoproliferation (lpr) or generalized lymphoproliferative disease (g1d) mutations o£ mice causes the development of systemic lupus erythematosus-like autoimmune syndromes that are characterized by severe lymphadenopathy and highly elevated serum immunoglobulin levels. Although the mutations are nonallelic, analysis of homozygous lpr/lpr and gidlgld mice on the ...

Abstract The mining industry produces massive amounts of waste that in contact with oxygen can result leaching metals. Access to a suitable cover-material for the mine is sometimes limited, creating driving force recycling industrial residues these purposes. Green liquor dregs (GLD), an residue from paper and pulp production, has potential be used sealing layer as amendment till. Though hydraul...

nia, San Diego. The tool has been extensively used to design and simulate free space opto-electronic interconnect systems.[1] Chatoyant is capable of performing end-to-end system simulations, with analyses including bit error rate (BER), insertion loss, cross talk, and mechanical tolerancing. Chatoyant’s optical library includes sources (VCSELs and MQW modulators), optical components (lenses, l...

Timely diagnosis and accurate identification of grape leaf diseases are decisive for controlling the spread disease ensuring healthy development industry. The objective this research was to propose a simple efficient approach improve accuracy with limited computing resources scale training image dataset based on deep transfer learning an improved MobileNetV3 model (GLD-DTL). A pre-training obta...

To avoid organ dysfunction as a consequence of tissue diminution or tumorous growth, a tight balance between cell proliferation and differentiation is maintained in metazoans. However, cell-intrinsic gene expression mechanisms controlling adult tissue homeostasis remain poorly understood. By focusing on the adult Caenorhabditis elegans reproductive tissue, we show that translational activation ...