BACKGROUND The Birch reduction of electron rich pyrroles does not occur readily. However, dissolving metal reduction with zinc under acidic conditions gives 3-pyrrolines (2,5-dihydropyrroles) in reasonable yield. This dissolving metal reduction was first reported by Knorr and Rabe in 1901 but since then has only been reported for the reduction of electron rich pyrroles. RESULTS The partial re...

s: Mouth dissolving tablet is the fast growing and highly accepted drug delivery system. This study was aimed at development of Ketorolac Tromethamine mouth dissolving tablet, which can disintegrate or dissolve rapidly once placed in the oral cavity. Conventional Ketorolac tromethamine tablet require water to swallow it and have disadvantages like low disintegration rate, low solubility etc.Ket...

Submitted 2011.09.28. Accepted for publication 2011.12.19. The convenience of administration and improved patient compliance are important in the design of oral drug delivery system which remains the preferred route of drug delivery inspite of various disadvantages. One such problem can be solved in the novel drug delivery system by formulating “mouth dissolving tablets” (MDTs) which disintegra...

Amlodipine besylate is a long‐acting calcium channel blocker used to treat chronic stable angina, vasospastic angina and hypertension. Amlodipine is a sparingly soluble orally administered drug and the rate of absorption is often controlled by the rate of dissolution. The rate of dissolution will increase by incorporating the drug in a fast dissolving dosage form. An attempt will be made to dev...

Hypertension is a major cause of concern not just in the elderly but also in the youngsters. An effort was made to formulate a fast dissolving film containing telmisartan which is used in the treatment of hypertension with a view to improve the onset of action, therapeutic efficacy, patient compliance and convenience. The major challenge in formulation of oral films of telmisatran is that it sh...

OBJECTIVES The objective of this study was to evaluate the influence of neutralizing a 2.5% NaOCl solution on its cytotoxicity, genotoxicity, and tissue-dissolving potential. STUDY DESIGN The cytotoxicity and the genotoxicity of Dakin, a 2.5% NaOCl solution, and a neutralized 2.5% NaOCl solution were assessed according to ISO 10993 standards. The weight of palatal mucosa samples placed in neu...

introduction: a desirable characteristic of root canal irrigants is the ability of dissolving soft tissues. sodium hypochlorite, an antibacterial and tissue solvent irrigant used in endodontic treatment is known to be toxic for periapical tissues. chlorhexidine gluconate, an effective antimicrobial agent, is another irrigant with limited tissue dissolving ability. a mixture of a tetracycline is...

Ondansetron is a highly selective serotonin (5-HT3) receptor blocker which inhibits serotonin to bind with serotonin 5-HT3 receptors and hence prevent the vomiting reflex induced by serotonin. This work aimed to develop rapid dissolving films of ondansetron for the treatment of chemotherapy induced nausea and vomiting. Rapid dissolving films were prepared by solvent casting method using pullula...

We investigate the dissolution of artificial fractures with three-dimensional, pore-scale numerical simulations. The fluid velocity in the fracture space was determined from a lattice-Boltzmann method, and a stochastic solver was used for the transport of dissolved species. Numerical simulations were used to study conditions under which long conduits (wormholes) form in an initially rough but s...

Automated knowledge management techniques critically depend on the availability of semantically enhanced documents which are hard to come by in practice. Starting from a detailed look at the motivations of users to produce semantic data, we argue that the authoring problem experienced by MKM is actually an author’s dilemma. An analysis of the content authoring process suggests that the dilemma ...