European Journal of Pharmaceutical Sciences 13 2001 123133 www.elsevier.nllocateejps. Modeling and comparison of dissolution profiles.To compare dissolution profiles between two drug products model dependent curve fitting, statistic analysis and model independent methods can be used. To compare dissolution profiles between two drug products model dependent curve fitting, statistic analysis and ...

Seismic wave attenuation is affected by wave-induced pore fluid dissolution. The mechanism of dissolution the mutual between different fluids caused pressure. Compared with traditional WIFF (wave-induced flow) mechanism, can predict seismic frequency band and be used in well-to-seismic calibration. Conventional methods neglect velocity dispersion interaction fluids, which will lead to errors pr...

ABSTRACT In recent years, the progress in hardware technology has made it possible for organizations to store and record large streams of transactional data. This results in databases which grow without limit at a rapid rate. This data can often show important changes in trends over time. In such cases, it is useful to understand, visualize and diagnose the evolution of these trends. When the d...

Clarithromycin (CLA), a broad-spectrum macrolide, is a poorly soluble drug with dissolution rate limited absorption. The aim of this investigation was to prepare CLA nanoparticles from a ternary ground mixture in the presence of sodium lauryl sulfate (SLS) and polyvinyl pyrrolidone (PVP) as co-grinding water-soluble compounds, in order to improve the drug dissolution rate. Different weight rati...

Abstract The flow of reactive fluids into porous media, a phenomenon known as infiltration, is important in natural and engineered systems. While most the studies this area cover theoretical experimental analyses linear acid flow, present work concentrates on radial conditions from wellbore field finding exact analytical solutions to moving boundary problems uniform dissolution front. Closed-fo...

A high density of local natural and human-induced ground deformation 11 structures resulting from the presence of evaporites occur extensively 12 around Zaragoza (NE Spain), posing risks to infrastructures, buildings and 13 agriculture. We studied the potential of a series of interferograms 14 constructed from 29 ERS -1/2 images to detect different types of ground 15 deformation related to evap...

Drug product performance testing is an important part of quality-by-design approaches, but this process often lacks the underlying mechanistic understanding of the complex interactions between the disintegration and dissolution processes involved. Whereas a recent draft guideline by the US Food and Drug Administration (FDA) has allowed the replacement of dissolution testing with disintegration ...

Curcumin is a phytoconstituent with wide range of biological activity. It is poorly soluble in water. In the present study a new dissolution medium was developed, as there is no validated dissolution method available in the literature. The composition of the dissolution medium was selected on the basis of solubility data at 37 degrees . Solubility data revealed that addition of surfactant may b...

The aims of the study were to observe the dissolution profile of four types of selected fruit powder fast dissolve tablet and apply different dissolution profile comparison methods, in order to select most applicable method. Spray dried powder of pitaya, pineapple, guava and mango were used as raw material. Each type of fruit powder tablet has identical dissolution profile. Dissolution profiles...

Naproxen is a poor water soluble, non-steroidal analgesic and anti-inflammatory drug. The enhancement of oral bioavailability of poor water soluble drugs remains one of the most challenging aspects of drug development. Although salt formation, solubilization and particle size reduction have commonly been used to increase dissolution rate and thereby oral absorption and bioavailability of low wa...