Due to complexity and interplay of variable gastrointestinal conditions with matrix tablets which are predominantly erosion controlled it is often difficult to predict in vivo release profile [1]. Nascent gel layer of matrix tablets is prone to mechanical stress which is difficult to simulate in vitro. Present study describes approaches to establish a biorelevant in vitro test for evaluation of...

The bioreduction of solid TNT by a Pseudomonas fluorescens strain was investigated in a stirred tank reactor. Experiments in which TNT beads were the only solids present indicated that the biodegradation mechanism is dissolution followed by degradation in bulk solution. Dissolution may limit the overall rate, in which case degradation can be enhanced through increased agitation. Since soil slur...

In situ atomic force microscopy (AFM) is used to differentiate temporally both structure and mechanism in the removal of fundamental structural units during the dissolution of zeolite A.

Introduction Dissolution is a characterization test commonly used by the pharmaceutical industry to guide formulation design and control product quality. Often, it is a required performance test for solid dosage forms,transdermal patches,and suspensions. It is also the only test that measures the rate of in vitro drug release as a function of time, which can reflect either reproducibility of th...

PURPOSE Skin exposure to soluble beryllium compounds causes systemic sensitization in humans. Penetration of poorly soluble particles through intact skin has been proposed as a mechanism for beryllium sensitization; however, this mechanism is controversial. The purpose of this study was to investigate the hypothesis that particulate beryllium compounds in contact with skin surface release ions ...

Unbiased zeolite dissolution removes defects in the structure, enabling retroactive assessment of crystallization history.