نتایج جستجو برای: discontinuation reason
تعداد نتایج: 118143 فیلتر نتایج به سال:
Abstract Background & aims: The Intrauterine contraceptive device is one of the safe, effective, longtime, and reversible and globally used contraceptive methods. The purpose of this research was to identify the factors associated with discontinuation of intrauterine contraceptive device among women referred to Sananda. health centers. Material & Methods: In this des...
OBJECTIVE Advanced therapy medicinal products (ATMPs) constitute a class of innovative products that encompasses gene therapy, somatic cell therapy, and tissue-engineered products (TEP). There is an increased investment of commercial and non-commercial sponsors in this field and a growing number of ATMPs randomized clinical trials (RCT) and patients enrolled in such trials. RCT generate data to...
BACKGROUND Lenalidomide is approved for treating transfusion-dependent anemia due to lower-risk del(5q) myelodysplastic syndromes (MDS). In clinical trials, rash was common, although severe rash was infrequent. To examine rash in patients with MDS treated with lenalidomide in the real world, the Celgene Global Drug Safety database was analyzed and compared with clinical trials. MATERIALS AND ...
B-cell receptor kinase inhibitor (KI) therapy represents a paradigm shift in chronic lymphocytic leukemia (CLL) management, but data on practice patterns after KI discontinuation and optimal sequencing are limited. We conducted a multicenter, retrospective, comprehensive analysis on 178 patients with CLL (ibrutinib = 143; idelalisib = 35) who discontinued KI therapy. We examined responses, toxi...
AIMS To evaluate persistence rates of patients receiving mirabegron therapy for overactive bladder (OAB) within our institution over a 6 month period, identify determinants of early discontinuation of therapy, and assess overall patient satisfaction with treatment. METHODS Hospital prescription data were analyzed in order to identify all patients who had been prescribed mirabegron in our inst...
BACKGROUND A clinical trial comparing the rate of discontinuation and tolerability of two post-exposure prophylaxis (PEP) regimens was performed. METHODS A total of 255 individuals attending the emergency rooms of six hospitals for exposure to HIV and criteria to receive PEP were randomized to receive zidovudine/lamivudine plus either lopinavir/ritonavir (n=131) or atazanavir (n=124; day 0). ...
OBJECTIVES The durability of combination antiretroviral therapy (cART) regimens can be measured as time to discontinuation because of toxicity or treatment failure, development of clinical disease or serious long-term adverse events. The aim of this analysis was to compare the durability of nevirapine, efavirenz and lopinavir regimens based on these measures. METHODS Patients starting a nevir...
CONTEXT Communication campaigns might be a viable means of improving contraceptive continuation; however, few such interventions aimed at reducing contraceptive discontinuation have been evaluated. METHODS Data were collected from independent samples of new injectable users in Nyando District, Kenya-site of a communication campaign to increase contraceptive continuation-and in a comparison di...
Methods Data were collected from medical charts of JIA patients followed at the pediatric rheumatology Unit from the State University of Campinas. Relevant clinical variables was observed as age, gender, age at diagnosis, subtype of JIA, age at start of MTX, the time from diagnosis to start the treatment with MTX (in months), response to MTX (yes / no) and whether there were adverse effects (ye...
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