the present study aimed to use a method for the synthesis of some 3, 4-dihydropyrimidin-2-(1h) - ones/thiones. the study tried to answer the question whether this reaction can be performed without solvent and with new catalyst or not. to find answer to the question, we described a novel protocol for the efficient synthesis of 3, 4-dihydropyrimidin-2-(1h)-one derivatives using aromatic aldehyde,...

We recently reported a novel synthesis of copper nanoparticles from copper sulphate utilizing the charge-compensatory effect of ionic liquid [bmim]BF(4) and ethylene glycol. The nanoparticles were characterized and found to be stable for one year. Here we hypothesize that the stabilized nanoparticles should be able to catalyze one-pot multicomponent organic reactions. We show that the nanoparti...

3,4-Dihydropyrimidinones of curcumin were synthesized in excellent yield by multi-component one-pot condensation of curcumin, substituted aromatic aldehydes and urea/thiourea under solvent free conditions using SnCl(2)·2H(2)O catalyst. All the synthesized compounds have been characterized by IR, (1)H NMR, (13)C NMR, Mass spectra as well as elemental analyses. The synthesized compounds 4a-n were...

Three-component reactions have emerged as useful methods because the combinationof three components to generate new products in a single step is extremely economical,among the multi-component reactions. A green, simple, efficient, and cost-effective procedure has been carried out by the synthesis of dihydropyrimidinonesin Biginelli’s condensation of ethyl cyanoacetate, aldehyde and urea or thio...

3,4-dihydropyrimidinones and their derivatives are synthesized via biginelli routes involving an aromatic aldehydes, ethylacetoacetates and urea in one-pot procedure by using cds nanoparticles as efficient heterogeneous catalyst in solvent-free conditions. compared with classical biginelli reaction reported in 1893, this new method provides much improved modification in terms of simplicity. the...

Background and Objective: Various biginelli compounds (dihydropyrimidinones) have been synthesized efficiently and in high yields under mild, solvent free and eco-friendly conditions in a one pot reaction of 1, 3-dicarbonyl compounds, aldehydes and urea/thiourea using Sodium Dodecyl Sulphate (SDS) as a novel catalyst under two experimental conditions. Methodology: The obtained products have bee...