Objective(s): The aim of this study is to examine the effect of different smoothing filters on the image quality and SUVmax to achieve the guideline recommended positron emission tomography (PET) image without harmonization. Methods: We used a Biograph mCT PET scanner. A National Electrical Manufacturers Association (NEMA) the International Electrotechnical Commission (IEC) body phantom was fil...

Computerized Adaptive Testing (CAT) refers to an efficient and personalized test mode in online education, aiming accurately measure student proficiency level on the required subject/domain. The key component of CAT is "adaptive" question selection algorithm, which automatically selects best suited for based his/her current estimated proficiency, reducing length. Existing algorithms rely some m...

AbstractObjective: To investigate the impact of respiratory motion on localization, and quantification lung lesions for the Gross Tumour Volume utilizing an in-house developed Auto3Dreg programme and dynamic NURBS-based cardiac-torso digitised phantom (NCAT). Methods: Respiratory motion may result in more than 30% underestimation of the SUV values of lung, liver and kidney tumour lesions. The m...

Purpose: To develop and test an integrated simulation system based on the digital Extended Cardio Torso (XCAT) phantom for 4-dimensional (4D) radiation therapy of lung cancer. Methods: A computer program was developed to facilitate the characterization and implementation of the XCAT phantom for 4D radiation therapy applications. To verify that patient-specific motion trajectories are reproducib...

A feasibility study of an electrical impedance mammography (EIM) system with a rotary planar electrode array, named RPEIM, is presented. The RPEIM system is an evolution of the Sussex MK4 system, which is a prototype instrument for breast cancer detection. Comparing it with the other planar electrode EIM systems, the rotation feature enables a dramatic increase in the number of independent meas...

PURPOSE We develop a realistic and flexible 4-D digital mouse phantom and investigate its usefulness in molecular imaging research. METHODS Organ shapes were modeled with non-uniform rational B-spline (NURBS) surfaces based on high-resolution 3-D magnetic resonance microscopy (MRM) data. Cardiac and respiratory motions were modeled based on gated magnetic resonance imaging (MRI) data obtained...

A phantom image is used to perform quality control in mammographic facilities. The interpretation of the ACR phantom images is depend upon the experience, visual threshold, scoring criteria and state of the observer. This paper summarizes the first step of automating this score using digital image processing, namely template matching via cross correlation, and suggests a metric for the visibili...

Microcalcification is one of the earliest and main indicators of breast cancer. Because dual-energy digital mammography could suppress the contrast between the adipose and glandular tissues of the breast, it is considered a promising technique that will improve the detection of microcalcification. In dual-energy digital mammography, the imaged object is a human breast, while in calibration meas...

The non-canonical amino acid labeling techniques BONCAT (bioorthogonal non-canonical amino acid tagging) and FUNCAT (fluorescent non-canonical amino acid tagging) enable the specific identification and visualization of newly synthesized proteins. Recently, these techniques have been applied to neuronal systems to elucidate protein synthesis dynamics during plasticity, identify stimulation-induc...

A digital brain phantom was created from available primate autoradiographic (AR) data for use in emission computed tomography studies. The tissue was radio-labelled with a functional analogue of the PET agent [18F]-fluoro-deoxyglucose (FDG). Following sacrifice of the animal, film records from serial 20 m thickness sections were digitized and calibrated to obtain ground truth 2D spatial distrib...