The conformational change for the alternating purine-pyrimidine polydeoxyribonucleotides i.e. poly d(A-T), poly d(G-C), and poly d(A-C) poly d(G-T) from a right-handed conformation at room temperature to the left-handed Z-DNA like double helix at elevated temperatures has been studied by UV spectroscopy, Raman spectroscopy, and by adiabatic differential scanning microcalorimetry (DSC) in the pr...

Hollow (air-filled) microparticles, i.e., microbubbles, provide a promising novel vehicle for both local delivery of therapeutic agents and simultaneous diagnostic ultrasound echo investigations. In this paper, we describe the synthetic routes for decorating the polymeric shell of a poly(vinyl alcohol)-based microbubble with low and high molecular weight ligands with pharmacological relevance. ...

Abstract Gas storage and recovery processes in shales critically depend on nano-scale porosity chemical composition, but information about the nanoscale pore geometry connectivity of kerogen, insoluble organic shale matter, is largely unavailable. Using adsorption microcalorimetry, we show that once strong sites within network are taken, gas even at very low pressure governed by width rather th...

Abstract Background Neuroblastoma is the most common solid childhood tumor outside central nervous system. Metastatic and relapsed disease in neuroblastoma patients still has a poor prognosis. New treatment methods to improve therapy outcomes for with advanced are urgently needed. However, clinical trials currently only allow testing few substances even fewer patients. This increases need advan...

Thermodynamic features related to preparation and use of self-assemblies formed between multilamellar and unilamellar zwitterionic liposomes and polynucleotides with various conformation and sizes are presented. The divalent metal cation or surfactant-induced adsorption, aggregation and adhesion between single- and double-stranded polyribonucleotides and phosphatidylcholine vesicles was followe...

Thermodynamic features related to preparation and use of self-assemblies formed between multilamellar and unilamellar zwitterionic liposomes and polynucleotides with various conformation and sizes are presented. The divalent metal cation or surfactant-induced adsorption, aggregation and adhesion between single- and double-stranded polyribonucleotides and phosphatidylcholine vesicles was followe...

This paper reports on the detection of nano-scale chemical variations in photosensitive polymers using scanning thermal probes fabricated from polyimide and metal thin films on a silicon substrate. The high thermal insulation achieved by these probes permits the measurement of thermal conductance variations <10 W/K. The probes are mechanically very compliant, with a typical a measured spring co...

We introduce a high sensitivity (1J/m) scanning microcalorimeter that can be used at high heating rates (10 °C/s). The system is designed using ultrathin SiN membranes that serve as a low thermal mass mechanical support structure for the calorimeter. Calorimetry measurements of the system are accomplished via resistive heating techniques applied to a thin film Ni heating element that also serve...

Cuprous oxide (Cu2O) nanocubes were synthesized by reducing Cu(OH)2 in the presence of sodium citrate at room temperature. The samples were characterized in detail by field-emission scanning electron microscopy, transmission electron microscopy, high-resolution transmission electron microscopy, X-ray powder diffraction, and N2 absorption (BET specific surface area). The equations for acquiring ...