We have reported that the differentiation-inducing factors (DIFs) DIF-1 and DIF-3, morphogens secreted from Dictyostelium discoideum, inhibit proliferation of several cancer cells via suppression of the Wnt/beta-catenin signaling pathway. However, the target molecules of DIFs involved in the anti-proliferative effects are still unknown. In the present study, DIF-1-tethered resins were synthesiz...

We investigated measurement equivalence in two antisocial behavior scales (i.e., one scale for adolescents and a second scale for young adults) by examining differential item functioning (DIF) for respondents from single-parent (n = 109) and two-parent families (n = 447). Even though one item in the scale for adolescents and two items in the scale for young adults showed significant DIF, the tw...

The dataflow interchange format (DIF) is a textual language that is geared towards capturing the semantics of graphical design tools for DSP system design. A key objective of DIF is to facilitate technology transfer across dataflow-based DSP design tools by providing a common, extensible semantics for representing coarse-grain dataflow graphs, and recognizing useful sub-classes of dataflow mode...

Short form measures from the Patient Reported Outcomes Measurement Information System® (PROMIS®) are used widely. The present study was among the first to examine differential item functioning (DIF) in the PROMIS Depression short form scales in a sample of over 5000 racially/ethnically diverse patients with cancer. DIF analyses were conducted across different racial/ethnic, educational, age, ge...

Separation of somatic cells from germ-line cells is a crucial event for multicellular organisms, but how this step was achieved during evolution remains elusive. In Dictyostelium discoideum and many other dictyostelid species, solitary amoebae gather and form a multicellular fruiting body in which germ-line spores and somatic stalk cells differentiate, whereas in Acytostelium subglobosum, acell...

tions in the mound stage of the cellular slime mold Dictyostelium discoideum has been developed. The model is based on current information about morphogenetic signaling that controls the differentiation of prestalk and prespore cells from differentiation-competent cells. The morphogens that can control the cell-type transitions are: (i) cAMP, which is required for both prestalk and prespore dif...

Title of Dissertation: EXAMINING DIFFERENTIAL ITEM FUNCTIONING FROM A LATENT CLASS PERSPECTIVE Karen Samuelsen, Doctor of Philosophy, 2005 Dissertation directed by: C. Mitchell Dayton Department of Measurement, Statistics and Evaluation Current approaches for studying differential item functioning (DIF) using manifest groups are problematic since these groups are treated as homogeneous in natur...

Slime moulds, such as Dictyostelium discoideum, have biochemical, physiological and probably developmental features in common with both plants and animals. During development separate Dictyostelium amoebae first aggregate into collecting centers to form small multicellular organisms which, in their slug form, can migrate over the substratum toward light. Eventually a slug culminates to form a f...

BACKGROUND The SF-36 is a very commonly used generic measure of health outcome in osteoarthritis (OA). An important, but frequently overlooked, aspect of validating health outcome measures is to establish if items work in the same way across subgroup of a population. That is, if respondents have the same 'true' level of outcome, does the item give the same score in different subgroups or is it ...