Because of the suggested role of energy consumption and the well-documented role of estrogens in the etiology of breast cancer, we have examined the effect of a 40% restriction of dietary energy consumption on the ability of administered 17beta-estradiol (E2) to induce mammary tumorigenesis in female ACI rats. Experiments herein test the hypothesis that at least part of the inhibitory effect of...

Longevity is a highly variable life history trait and its variation is attributable to both genetic and environmental factors. Exploring well-known environmental factors in a new model system is a useful approach to explore taxonomic variation in plasticity of longevity. We examined responsiveness of the Daphnia pulex clone TCO to potentially related interventions that have been reported to ext...

BACKGROUND/AIMS Although high salt intake is thought to accelerate renal progression in proteinuric kidney disease, it is not known whether strict dietary salt restriction could delay renal inflammation and interstitial fibrosis. Here, we sought to answer this question in a rat model of adriamycin-induced nephrotic syndrome. METHODS Adriamycin was administered via the femoral vein in a single...

Dietary restriction is a robust and conserved intervention to slow aging and extend lifespan. In this issue of Cell Metabolism, Hou et al. (2016) use a systems biology approach in C. elegans to uncover key molecular nodes underlying the transcriptomic response to dietary restriction and predict novel regulators of lifespan.

● Dietary therapy is a key element in the conservative medical management of chronic renal failure (CRF) in dogs and cats. ● Appropriate dietary modifications can alleviate clinical signs of uremia and may help to slow progression of renal damage. ● Although the restriction of dietary protein is of clinical benefit in uremic patients, excessive protein restriction can cause protein malnutrition...

PTEN loss is considered a biomarker for activated phosphoinositide 3-kinase (PI3K)/ AKT, a pathway frequently mutated in cancer, and was recently shown to confer resistance to dietary restriction. Here, we show that Pten loss is not suffi cient to drive AKT activation and resistance to dietary restriction in tumors with low growth factor receptor levels. We describe a murine Pten-null Kras-driv...

Dietary restriction extends lifespan in a wide variety of animals, including Drosophila, but its relationship to functional and cognitive aging is unclear. Here, we study the effects of dietary yeast content on fly performance in an aversive learning task (association between odor and mechanical shock). Learning performance declined at old age, but 50-day-old dietary-restricted flies learned as...

Lifespan in individually housed medflies (virgins of both sexes) and daily reproduction for females were studied following one of 12 dietary restriction (DR) treatments in which the availability of high-quality food (yeast-sugar mixture) for each fly was based on a Markov chain feeding scheme--a stochastic dietary regime which specifies that the future dietary state depends only on the present ...