Doxorubicin (DOX) is an antineoplastic drug widely used for the treatment of various types of cancer; however, it can induce severe side effects, such as myelosuppression and cardiotoxicity. Sanyang Xuedai (SYKT) is a natural medicine originating from an ancient prescription of the Dai nationality in Southwest China. With eight Chinese herbal medicines, including sanguis draconis, radix et rhiz...

Previous studies have indicated that nitric oxide (NO) released from Kupffer cells modulates biological viability of cocultured hepatoma cells. This study was designed to evaluate the mechanisms by which Kupffer cells synthesize and release NO in reponse to cocultured hepatoma cells. Kupffer cells isolated from male Wistar rats were cocultured with rat hepatoma cell line, AH70 cells. The sum of...

Objective: The role of norepinephrine (NE) on growth, adhesion and invasion methicillin-resistant Staphylococcus aureus (MRSA) ATTC 43300 was examined in human osteoblast (HOB) cells. effects NE and/or MRSA the viability cell death pathways HOB cells were also investigated. Furthermore, alterations bacterial response to oxidative stress (H2O2) analyzed presence/ absence NE. Materials Methods: B...

OBJECTIVE To study the effects of high-protein versus high-carbohydrate diets on various metabolic end points (glucoregulation, oxidative stress [dichlorofluorescein], lipid peroxidation [malondialdehyde], proinflammatory cytokines [tumor necrosis factor-α and interleukin-6], adipokines, and resting energy expenditure [REE]) with high protein-low carbohydrate (HP) and high carbohydrate-low prot...

Hatoum, Ossama A., David G. Binion, Hiroto Miura, Gordon Telford, Mary F. Otterson, and David D. Gutterman. Role of hydrogen peroxide in ACh-induced dilation of human submucosal intestinal microvessels. Am J Physiol Heart Circ Physiol 288: H48– H54, 2005. First published September 2, 2004; doi:10.1152/ajpheart. 00663.2004.—The endothelium plays an important role in maintaining vascular homeosta...

Endothelial cells increase their secretion of the cytokine interleukin-6 (IL-6) during hypoxia, which then acts in an autocrine fashion to increase the permeability of cell monolayers. These responses are attenuated by antioxidants, suggesting that reactive oxygen species (ROS) participate in signaling in hypoxic endothelium. We tested whether mitochondria are responsible for these ROS in human...

Background: The musculoskeletal repair, in most cases, follows the typical inflammatory process. Although majority of treatments result good prognosis, knowledge concerning basic biochemical principles, regeneration and repair mechanisms skeletal muscles may help recovery accelerate return to sport, helping carefully choose more appropriate therapeutic techniques for injury management. Objectiv...

ARTICLES DISCUSSED: Damsgaard, C., Lauridsen, H. Deep vascular imaging in the eye with flow-enhanced ultrasound. Journal of Visualized Experiments. (176), e62986 (2021). Macouzet-Romero, F. J., Ochoa-Máynez, G. A., Pérez-García, O., Pérez-Aragón, B. Lima-Gómez, V. Evaluation capillary and other vessel contribution to macular perfusion density measured optical coherence tomography angiography. (...