نتایج جستجو برای: dicer1 protein

تعداد نتایج: 1235057  

2015
Da Sol Kim Sun Young Lee Jung Hee Lee Yong Chan Bae Jin Sup Jung

The elucidation of the molecular mechanisms underlying the differentiation and proliferation of human adipose tissue-derived stromal cells (hADSCs) represents a critical step in the development of hADSCs-based cellular therapies. To examine the role of the microRNA-103a-3p (miR-103a-3p) in hADSCs functions, miR-103a-3p mimics were transfected into hADSCs in order to overexpress miR-103a-3p. Ost...

Journal: :Brain Sciences 2023

DICER1 syndrome is a tumor predisposition caused by abnormal micro-RNA processing which leads to variety of benign and malignant neoplasms in many organ systems, including the central nervous system. This paper reports case primary intracranial sarcoma, DICER1-mutant, patient with germline variant thought most likely be de novo. The ten-year-old boy who presented acutely altered level conscious...

2012
Ida Björkgren Lauri Saastamoinen Anton Krutskikh Ilpo Huhtaniemi Matti Poutanen Petra Sipilä

BACKGROUND The postnatal development of the epididymis is a complex process that results in a highly differentiated epithelium, divided into several segments. Recent studies indicate a role for RNA interference (RNAi) in the development of the epididymis, however, the actual requirement for RNAi has remained elusive. Here, we present the first evidence of a direct need for RNAi in the different...

2011
Yannick Romero Oliver Meikar Marilena D. Papaioannou Béatrice Conne Corinne Grey Manuela Weier François Pralong Bernard De Massy Henrik Kaessmann Jean-Dominique Vassalli Noora Kotaja Serge Nef

BACKGROUND Spermatogenesis is a complex biological process that requires a highly specialized control of gene expression. In the past decade, small non-coding RNAs have emerged as critical regulators of gene expression both at the transcriptional and post-transcriptional level. DICER1, an RNAse III endonuclease, is essential for the biogenesis of several classes of small RNAs, including microRN...

Journal: :Haematologica 2015
Youshan Zhao Dong Wu Chengming Fei Juan Guo Shuncheng Gu Yang Zhu Feng Xu Zheng Zhang Lingyun Wu Xiao Li Chunkang Chang

Although it has been reported that mesenchymal stromal cells are unable to provide sufficient hematopoietic support in myelodysplastic syndrome, the underlying mechanisms remain elusive. In this study, we found that mesenchymal stromal cells from patients with myelodysplastic syndrome displayed a significant increase in senescence, as evidenced by their decreased proliferative capacity, flatten...

2015
Anna Kurzynska-Kokorniak Natalia Koralewska Maria Pokornowska Anna Urbanowicz Aleksander Tworak Agnieszka Mickiewicz Marek Figlerowicz

There is increasing evidence indicating that the production of small regulatory RNAs is not the only process in which ribonuclease Dicer can participate. For example, it has been demonstrated that this enzyme is also involved in chromatin structure remodelling, inflammation and apoptotic DNA degradation. Moreover, it has become increasingly clear that cellular transcript and protein levels of D...

Journal: :The Journal of Experimental Medicine 2008
Adrian Liston Li-Fan Lu Donal O'Carroll Alexander Tarakhovsky Alexander Y. Rudensky

Regulatory T (T reg) cells are indispensable for preventing autoimmunity. Incumbent to this role is the ability of T reg cells to exert their suppressor function under inflammatory conditions. We found that T reg cell-mediated tolerance is critically dependent on the Dicer-controlled microRNA (miRNA) pathway. Depletion of miRNA within the T reg cell lineage resulted in fatal autoimmunity indist...

2015
Jasdeep Singh Chandra Sekhar Mukhopadhyay Jaspreet Singh Arora Simarjeet Kaur

Dicer, an ribonuclease type III type endonuclease, is the key enzyme involved in biogenesis of microRNAs (miRNAs) and small interfering RNAs (siRNAs), and thus plays a critical role in RNA interference through post transcriptional regulation of gene expression. This enzyme has not been well studied in the Indian water buffalo, an important species known for disease resistance and high milk prod...

Journal: :Development 2011
Noa Davis Eyal Mor Ruth Ashery-Padan

The embryonic ocular neuroepithilium generates a myriad of cell types, including the neuroretina, the pigmented epithelium, the ciliary and iris epithelia, and the iris smooth muscles. As in other regions of the developing nervous system, the generation of these various cell types requires a coordinated sequence of patterning, specification and differentiation events. We investigated the roles ...

Journal: :Klinicka Onkologie 2019

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