Introduction of ester groups into positions 4 and 5 of 3-iodopyridazines (1,2) by redox decomposition of the oxyhydroperoxide of ethyl pyruvate in a sulfuric acid/toluene two-phase system affords trifunctional pyridazine building blocks (3,4a) in a single step. Iodoarenes and -hetarenes are known as useful synthons for C-C bond formation by palladium-catalyzed cross-coupling reactions. In the p...
